This paper presents the synthesis, characterisation, andin vitrotesting of homogenous and heterogeneous materials containing silver nanoparticles (nanoAg). Three types of antiseptic materials based on collagen (COLL), hydroxyapatite (HA), and collagen/hydroxyapatite (COLL/HA) composite materials were obtained. The synthesis of silver nanoparticles was realized by chemical reaction as well as plasma sputtering deposition. The use of chemical reduction allows the synthesis of homogenous materials while the plasma sputtering deposition can be easily used for the synthesis of homogeneous and heterogeneous support. Based on thein vitroassays clear antiseptic activity againstEscherichia coliwas relieved even at low content of nanoAg (10 ppm).
The paper describes the preparation, characterisation, and testing of tetracycline loaded collagen-carboxymethylcellulose/ hydroxyapatite ternary composite materials. The synthesis of this drug delivery system consists in two steps: the first step is the mineralization of collagen-carboxymethylcellulose gel while the second step corresponds to the loading of the ternary composite material with tetracycline. The obtained DDS is characterised by physicochemical, morphological, and release behaviour by using FTIR spectroscopy and microscopy, scanning electron microscopy, and UV-VIS spectroscopy. Based on the release study, it can be assumed that tetracycline is released in a prolonged way, assuring at least 6 days of antiseptic properties.
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