Objective This study aimed to evaluate the effect of 0.2% chlorhexidine (CHX) gel on wound healing after tooth extraction.
Materials and Methods A single blind, randomized controlled trial was performed recruiting 32 participants who underwent dental extractions. Patients were randomly allocated for CHX group or placebo group. The primary outcomes were wound closure measured with calipers and healings were assessed by Landry et al index after 7 days of topical application of allocated gels on extraction sites.
Results The wound closures were greater in CHX group compared with placebo group and healing scores were correlated with the use of CHX gel (p-value < 0.05).
Conclusion In a population of healthy nonsmoker adults, application of 0.2% CHX gel twice a day for 7 days after tooth extraction has a beneficial effect on wound healing.
Objectives: Being the most common type of oral malignancies, oral squamous cell carcinoma is initiated by epithelial dysplasia, which can be marked by the expression of nuclear factor kappa B and cyclooxygenase 2. Curcumin has been known for its anti-cancer potential. The objective of this study was to evaluate the anti-cancer potential of curcumin on oral squamous cell carcinoma based on the expression of the nuclear factor kappa B and cyclooxygenase 2 during epithelial dysplasia stage. Methods: This experimental study was performed on 35 Sprague Dawley rats at the Veterinary Medicine Faculty, Bogor Agricultural Institute, Indonesia. At the beginning of the experiments, all rats were induced by 100 µg 0.5% 7,12-dimethylbenz(a)anthracene every 2 days for the duration of 28 days. Once epithelial dysplasia stage was reached, all rats were then randomly divided into control group (that did not receive curcumin) or the experimental group (the group that received curcumin for the next 4 weeks). After 4 weeks, the histopathological examination of haematoxylin and eosin and immunohistochemistry examination were conducted. Data were gathered and analyzed by using the Wilcoxon–Mann–Whitney test. Results: The results of the current study revealed that the experimental group showed significantly less nuclear factor kappa B (p < 0.01) and cyclooxygenase 2 (p = 0.03) expressions compared to the control group. Conclusion: The results of the study suggested that curcumin was effective in suppressing nuclear factor kappa B and cyclooxygenase 2 expression in experimentally induced oral squamous cell carcinoma. Future studies investigating curcumin anti-cancer potential in a further stage of oral squamous cell carcinoma, as well as the involvement of other components that might improve curcumin anti-cancer potential, are of importance.
Objectives: Odontectomy is a common procedure in the extraction of third molars. Assessment of the difficulty level of extraction of third molars can be evaluated based on the classification of impaction. This article aims to discuss how the classification of impaction in third molars evaluates the difficulty of odontectomy treatment through radiographic examination.
Literature Review: Literature search was carried out from various electronic databases with article inclusion criteria that discussed the validity of third molar impaction classification through radiography.
Conclusion: Based on the findings of this review, it can be concluded that various stratified classifications are suggested as index that can be considered and recommended in the assessment of the difficulty level of third molar odontectomy.
The aim of this study was to analyze the potential for topical administration of Eleutherine palmifolia (l.) merr extract gel in the healing proccess of wound with osteitis alveolar as a complication after tooth extraction in Sprague dawley mice by observing fibroblast cell area, collagen density, and amount of osteogenesis. Material and Methods: This study used a true experimental research method conducted on Sprague Dawley mice. Sample were divided into 3 groups, namely K1 (osteitis alveolar was not given any treatment), K2 (osteitis alveolar mice were given iodoform paste application every 3 days), and K3 (osteitis alveolar mice were given application of the extract gel Eleutherine palmifolia (l.) merr topically). On day 3, 5 and 10 necropsy was done and the tooth sockets in the form of soft tissue together with hard tissue was taken, then preparations were made and stained with masson trichrome to examined fibroblasts, collagen and osteogenesis. Results: Topical application of the extract gel Eleutherine palmifolia (l.) merr showed the mean value of fibroblasts area and collagen density and the amount of osteogenesis were comparable to iodoform paste in alveolar osteitis healing. Conclusion: this study is that the application of Eleutherine Palmifolia (l) merr extract gel has almost the same effectiveness as iodoform paste
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.