Patterned glycine crystals nucleated on functionalized metallic square islands. This approach can be used to fabricate particles with micron dimensions and screen solid forms under different conditions. The size of the glycine crystals is controlled by the dimensions of the islands. High energy metastable beta-glycine crystallizes on small metallic islands, whereas for large islands, the polymorphic outcome becomes biased toward the alpha-form.

Minimally invasive repair of pectus excavatum based on a novel morphology-tailored, patient-specific approach is effective for quality repair of the full spectrum of pectus excavatum, including asymmetry and adult patients. Continuous technical refinements have significantly decreased the complication rates and postoperative morbidity.

This study demonstrates the effect of the solution pH on the polymorphic outcome of glycine by evaporation-driven crystallization from aqueous solution. More than 2000 solution droplets under identical conditions were generated using a patterned self-assembled monolayers (SAMs) substrate. Each droplet on the substrate serves as an independent crystallization trial. Glycine nucleated inside the droplets through solvent evaporation, and their polymorphic forms were identified via Raman microscopy. Three different polymorphic forms of glycine (R-, β-, and γ-forms) simultaneously crystallized at all conditions employed. The probability of producing the thermodynamically stable γ-glycine from acidic (pH 3.40) or basic solution (pH 10.10) droplets significantly increased when compared with neutral aqueous solution (pH ∼ 6.00) droplets.