Hasankeyf is an ancient city located on the shores of the Tigris River in Batman Province, southeast Turkey. The town and some of its surrounding villages will be soon submerged, due to the construction of Ilısu Dam, which will force the residents to move to new settlements. The aim of the present study was to collect and record the traditional knowledge regarding the indigenous wild plants that will be submerged by this flooding. The study was carried out between March 2017 and April 2019. Interviews were conducted with 72 women and 53 men in the town center and 22 rural settlements, with a focus on the five villages that are due to be submerged. Information about a total of 86 wild edible plants belonging to 32 families was recorded. Interviewees reported that these were used as green vegetables (45 taxa), ripe fruits and seeds (25 taxa), seasoning and preservatives (16 taxa), beverages (nine taxa), and children’s snacks (seven taxa). In addition, the data were analyzed on the basis of the cultural importance index to determine the cultural significance of these wild edible plants and the informants’ knowledge about them. Culturally, the most significant species included <em>Mentha longifolia</em>, <em>Polygonum cognatum</em>, <em>Rosa canina</em>, <em>Chenopodium album</em>, <em>Urtica dioica</em>, <em>Amaranthus retroflexus</em>, and <em>Malva neglecta</em>. In addition, the data were compared with relevant data in the ethnobotanical literature of Turkey and its neighboring countries. Several uses mentioned here are documented here for the first time. Our research highlights the importance of wild edible plants in the daily lives of inhabitants and their potential for economic use. The present study also provides information for future archaeobotanical studies in this region.

Hasankeyf is an ancient city, dating back to more than 10,000 years, in the Southeast Anatolia Region of Turkey. The area is separated by the Tigris River on both sides and located in the Batman province. However, as a result of a dam project, in February 2020, this ancient city and some of its surrounding villages were totally flooded. The residents were moved to new settlements. This study aimed to prevent the possible loss of ethnomedicinal knowledge of plants due to migration as well as to pass on this knowledge to the future generations. The field studies were conducted between March 2017 and November 2019 in the city center and 22 rural settlements of Hasankeyf. Also, the areas where intensive migration was experienced were visited frequently. Interviews were conducted with a total of 131 participants (76 women and 55 men) while gathering plants with them. Information was collected through interviews and questionnaires. The results were analyzed by quantitative indices of information consensus factor (FIC) and use value (UV). A total of 94 plant taxa belonging to 40 families were identified in the study area. The most common medicinal plant families are Lamiaceae (13), Asteraceae (8), Rosaceae (6), Malvaceae (6), Amaryllidaceae (5), Brassicaceae (4), and Solanaceae (4). The most common preparations were infusion, fresh application, and crushing. The taxa having the highest count of use value (UV) were Teucrium polium, Matricaria aurea, Urtica dioica, Mentha longifolia, and Quercus brantii. Besides, the recorded ailments were grouped into categories based on information provided by the interviewees. The most important use categories among the informants were diabetes, gastrointestinal disorders, respiratory disorders, and dermatological disorders. The present study represents the first medical-ethnobotanical documentation and analysis of the traditional use of medicinal plants in Hasankeyf.