Background: Dental caries is a multifactorial disease characterized by dental tissue damage caused by the production of bacterial acids. The bacteria play the most role in the occurrence of caries is Streptococcus mutans. Turmeric extract (Curcuma longa) has been studied can inhibit bacterial growth because it contains essential oils and curcumin. The purpose of this study was to determine the inhibitory power of turmeric extract 5%, 10%, 20%, and 40% on the growth of Streptococcus mutans bacteria. Methods: Studies with true experimental design using a post test only control group design have been carried out on Streptococcus mutans bacteria. Turmeric extract was made by maceration method into 96% ethanol so that the required concentration was obtained (5%, 10%, 20%, dan 40%). The inhibition testing is done by the disk-diffusion method. Data were analyzed using the Kruskal-Wallis test on SPSS version 20 due to the data were not normally distributed. Results: The results showed that phytochemical assessment of turmeric extract showed positive results on phenol, essential oil, saponins, tannins, and flavonoids. The average value of the inhibitory zone diameter of Streptococcus mutans bacteria formed in turmeric extract concentrations of 5%, 10%, 20%, and 40% is 0 mm where there are significant differences compared to positive controls (P < 0.05) Conclusion: Various doses of turmeric extract couldn't inhibit the growth of Streptococcus mutans bacteria
Periodontal disease is an infectious disease, could be result loose of the teeth. This research is to prove that the applying 0.7% tetracycline hcl gel on rat gingival sulcus result higher number of fibroblasts and collagen synthesis which are marked by the thicker of rat periodontal ligament. The study was a randomized post test only control group design experimental study on 32 white male rats which are inducted by lipopolyssaccaride (LPS) for 8 days. And then rats divided into control group were given placebo, and treatment group were given 0.7% tetracycline HCL gel. On 10th days, the rats were euthanazided for taken mandibula alveolar bone tissue sampling and histological preparations were made by HE (Harris Hematoxylin-Eosin) staining. The data were analyzed using SPSS program processed using Shapiro Wilk for normality test and then continued using independent t-test. The result of this research is the mean number of fibroblasts at treatment group by administration of 0.7% tetracycline HCL gel (148.38±5.11 units) was higher than the control group (113.19±5.39 units). The mean of collagen synthesis was showed by the thickness of periodontal ligamen at group treated 0.7% tetracycline HCL gel (338.65±57.28 µm) was higher than the control group (225.50±45.29 µm). The mean number of fibroblast cell and thickness of periodontal ligament were statistically different (p<0.05). Thus, it is concluded that 0.7% tetracycline HCL gel enhance the number of fibroblasts cell and the thickness of periodontal ligament in rat with periodontal disease.
Introduction: Calcium is one of the major inorganic components in the hydroxyapatite cystal [Ca10(PO4)6(OH)2] of dental enamel. Calcium enamel can dissolve at low pH and this is an early sign of dental erosion. One of the factors causing the solubility of calcium enamel is consumption of soft drink with low pH such as carbonated and isotonic drinks. The purpose of this study was to determine differences patterns of calcium enamel solubility on soaking the teeth between carbonated drinks and isotonic drinks. Method: This study was a laboratory experiment (invitro) with time series design. This study used permanent premolars human teeth soaked into carbonated drinks and isotonic drinks for 5, 15, 30, 45, and 60 minutes, then measured calcium enamel content dissolved using a spectrophotometer. Data were analyzed by saphiro wilk test of normality and followed by Independent T Test. Result: The result showed that p value on carbonated beverage was 0.020 and in isotonic drink was 0.026. The p value of both drinks was below 0.05 (p<0.05) indicating that there was significant difference of enamel calcium solubility in carbonated drinks and isotonic drinks at each time. Conclusion: The conclusions of this study was patterns of calcium enamel solubility on soaking the teeth between carbonated drinks and isotonic drinks were different. The solubility of calcium in carbonated drinks has decreased in the next minutes, while calcium enamel solubility in isotonic drinks has increased in the next minutes. Latar Belakang: Kalsium merupakan salah satu komponen anorganik utama kristal hidroksiapatit [Ca10(PO4)6(OH)2] pada enamel gigi. Kalsium enamel dapat larut pada pH yang rendah dan merupakan tanda awal terjadinya erosi gigi. Salah satu faktor yang dapat menyebabkan larutnya kalsium enamel adalah konsumsi minuman ringan dengan pH yang rendah seperti minuman berkarbonasi dan minuman isotonik. Tujuan penelitian ini adalah untuk mengetahui perbedaan pola kelarutan kalsium enamel pada perendaman gigi antara minuman ringan berkarbonasi dan minuman isotonik. Metode: Penelitian ini merupakan penelitian eksperimental laboratorium (invitro) dengan studi time series. Penelitian ini menggunakan gigi premolar permanen manusia yang direndam kedalam minuman berkarbonasi dan minuman isotonik selama 5, 15, 30, 45, dan 60 menit, kemudian dilakukan pengukuran kadar kalsium enamel yang terlarut dengan menggunakan spektrofotometer. Data dianalisis menggunakan saphiro wilk test of normality dan dilanjutkan dengan Independent T Test. Hasil: Hasil analisis menunjukan nilai p pada minuman berkarbonasi adalah 0,020 dan pada minuman isotonik adalah 0,026. Nilai p pada kedua minuman berada dibawah 0,05 (p<0,05) yang menunjukan bahwa terjadi perbedaan kelarutan kalsium enamel yang signifikan pada minuman berkarbonasi dan minuman isotonik disetiap waktunya. Simpulan: Dapat disimpulkan bahwa pola kelarutan kalsium enamel pada perendaman gigi dalam minuman berkarbonasi dan minuman isotonik memiliki perbedaan. Kelarutan kalsium pada minuman berkarbonasi mengalami penurunan pada perendaman menit-menit selanjutnya, sedangkan kelarutan kalsium enamel pada minuman isotonik mengalami peningkatan pada perendaman menit-menit selanjutnya.
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