The Aim: To evaluate the association of TSHR gene polymorphism rs2268458 with some Physio-biochemical parameters among hypothyroidism women. Methods: This study included 51 hypothyroidism women and 43 healthy women as a control group. Some Physio-biochemical (body mass index (BMI), cytochrome 450 1A1 (CYP1A1), calcium, and phosphorus) and hormonal assay (Osteopontin (OPN), thyroid stimulating hormone (TSH), fT3, fT4 and Calcitonin (CT)) assay were performed. Genotyping of rs-2268458 of TSHR gene was carried out using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique. Results: TSHR rs2268458 was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for disease by OR= 4.393, CI=1.42-13.53 where TC and CC genotypes were associated with high BMI, while TC genotype was associated with high calcitonin and CYP1A1 levels. Conclusion: The TSHR rs2268458 polymorphism was associated with hypothyroidism in Iraqi women and allele C can be a risk factor for some Physio-biochemical and hormonal disorder in hypothyroidism women.

Objective: This study aimed to evaluate the relationship between thalassemia disease and body mass index (BMI) and the correlation with blood group of thalassemia patients.Methods: The study includes 260 persons (male+female), 200 persons were thalassemia patient (120 male and 80 female), and 60 healthy persons (30 male and 30 female) as control group; furthermore, people were divided into three group according to age 1–9, 10–19, and >20 years, and BMI and blood group were measured for all patients and healthy people.Results: The results showed that the frequency of thalassemia in male (65%) is higher than in female (40%); as well as, the results showed that the age group (10–19) years is more frequent in male, while in female, the age group (1–9) years is more frequent. The results of BMI revealed a significant decrease (p<0.05) in all groups of thalassemia patients compared with healthy group; as well as, the results of blood group showed that the group (O+) is the more frequent 34% in comparison with the other blood groups.Conclusion: We conclude that there was a strong relationship among gender, blood group (the most common blood group observed is O +ve), and BMI with thalassemia.

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Multiple myeloma (MM) still an incurable disease that require better recognition and more research. Many previous studies shown the interaction between myeloma cells and bone marrow stromal cells for the initiation and progression of multiple myeloma . Many chemokines and their receptors including interleukin-6 (IL-6) an play important roles in this interaction. The main purpose of this study is assess the serum level of IL-6 and Lactate dehydrogenase on stage-III of MM patients and healthy controls then Finding the correlation with creatinine and calcium levels. Serum level of IL-6 , Lactate Dehydrogenase , creatinine and calcium levels of (30) MM patients diagnosis at stage -III according to International staging System (ISS) were measurement. The results for these parameters compare with (30) age-and sex-matched healthy controls groups. The results were showed that the mean levels of IL-6 , Lactate dehydrogenase , creatinine and calcium (increased or decreased)high significant (p≤0.001) when compared with healthy controls . The results of the study suggested the important role of chemokines including IL-6 in the progression of the disease and its relationship with some biochemical parameters , especially in the stage-III of the disease.