Highlights d CD146 deficiency reduces Rictor expression and mTORC2 activity in human cells d CD146 stabilizes Rictor from UPS degradation by interaction via its KKGK motif d Rictor-CD146 interaction depends on the growth factor (GF) activation of RTK d mTORC2 activation by GFs can be regulated by Rictor stability via CD146
Highlights d CD146 deficiency reduces Rictor expression and mTORC2 activity in human cells d CD146 stabilizes Rictor from UPS degradation by interaction via its KKGK motif d Rictor-CD146 interaction depends on the growth factor (GF) activation of RTK d mTORC2 activation by GFs can be regulated by Rictor stability via CD146
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