A palladium‐catalyzed intermolecular annulation and arylation cascade between internal alkynes and o‐triazole bromobenzenes was developed, delivering to various polysubstituted [1,2,3]triazolo[1,5‐a]quinolines. Broad substrate scope, great functional group tolerance and simple operation of this transformation, hold great synthetic potential for the rapid construction of fused N‐heterocycles with biologically activity.
This paper introduced an economic and environmental approach to 3-bromoindenes from simple and readily available o-(alkynyl)styrenes via a Pd-catalyzed cascade cyclization including bromopalladation/Heck cross-coupling/β-H elimination. With O2 as the sole oxidant and KBr as bromide source, a series of poly-substituted 3-bromoindenes were synthesized with high chemoselectivity avoiding the use of CuBr2.
The hydrodehalogenation of halogenated organic compounds which have brought serious pollution to the environment can not only transform them into other usefull chemicals, but also reduce their pollution in the field of environment. A Pd-catalyzed hydrodehalogenation of o-triazole aryl halides is introduced, taking Pd/C as catalyst and Et 3 N as base, reductant and hydrogen source. This strategy is highlighted by appealing features such as simple reaction condition, recyclable catalyst, and good yield etc.
This paper developed a new method for the construction of polysubstituted indenes. And a number of multisubstituted indenes have been synthesized from functional o-alkenyl bromobenzenes and alkynes in good yields through palladium-catalyzed annulations in N,N-dimethylformamide (DMF) taking Na 2 CO 3 as base. The methodology tolerates a variety of functional groups with simple reaction conditions and the catalyst can be reused.
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