Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critical role in epigenetic DNA demethylation, neuroplasticity, and neuroprotection, according to accumulating evidence. This article provided an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, focusing on major psychosis, depression, autism, stroke, seizure, dementia, Parkinson’s disease, and autoimmune diseases of the nervous system.
Prognostics and health management (PHM) with failure prognosis and maintenance decision-making as the core is an advanced technology to improve the safety, reliability, and operational economy of engineering systems. However, studies of failure prognosis and maintenance decision-making have been conducted separately over the past years. Key challenges remain open when the joint problem is considered. The aim of this paper is to develop an integrated strategy for dynamic predictive maintenance scheduling (DPMS) based on a deep auto-encoder and deep forest-assisted failure prognosis method. The proposed DPMS method involves a complete process from performing failure prognosis to making maintenance decisions. The first step is to extract representative features reflecting system degradation from raw sensor data by using a deep auto-encoder. Then, the features are fed into the deep forest to compute the failure probabilities in moving time horizons. Finally, an optimal maintenance-related decision is made through quickly evaluating the costs of different decisions with the failure probabilities. Verification was accomplished using NASA’s open datasets of aircraft engines, and the experimental results show that the proposed DPMS method outperforms several state-of-the-art methods, which can benefit precise maintenance decisions and reduce maintenance costs.
α-KTX, alpha-potassium channel toxin peptides; ADWX-1, autoimmune drug from Wenxin group; APC, anterior piriform cortex; BK channel, large conductance voltage and Ca 2+ -activated potassium channel; CS, cysteine-stabilized; ChTX, Charybdotoxin; DMEM, Dulbecco's modified Eagle's medium; DRG, dorsal root ganglion; E. coli, Escherichia coli; GPCR, G protein-coupled receptor; HPLC, High Performance Liquid Chromatography; IC 50 , concentration of half-maximal inhibition; IL-2, interleukin-2; ImKTX58, number 58 potassium channel toxin peptide identified from the venom gland cDNA library of Isometrus maculatus; ImKTX88, number 88 potassium channel toxin peptide identified from the venom gland cDNA library of Isometrus maculatus; κ-BUTX-Im1a, kappa-Buthitoxin-Im1a; Kv channel, voltage-gated potassium channel; LmKTX10, number 10 potassium channel This article has not been copyedited and formatted. The final version may differ from this version.
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