Background: In recent years, ultrasound elastography (USE) has been the main diagnostic technique for benign and malignant thyroid nodules. However, it cannot display the blood flow signals of nodules with smaller diameters clearly, which decreases its diagnostic accuracy.Methods: Chinese and English databases were searched using "ultrasonic elastography", "benign and malignant thyroid nodules", and "diagnose" as the search terms. RevMan 5.3 software was used for metaanalysis.Results: A total of 11 randomized controlled trials (RCTs) were included. Eight articles analyzed clinical symptoms, and the heterogeneity test results were Chi 2 =7.46, df=7, I 2 =6%, and P=0.38; and Z=11.44, OR =14.58, 95% confidential interval (CI): 9.21-23.07, and P<0.01. The diagnostic efficacy of USE was analyzed in 8 articles, and the heterogeneity test results were Chi 2 =3.03, df=7, I 2 =0%, and P=0.88; and Z=6.33, OR =7.47, 95% CI: 4.01-13.93, and P<0.01. The pathological diagnosis results of randomized controlled trials were analyzed in 10 literatures, and the heterogeneity test results were Tau 2 =0.78, Chi 2 =20.97, df=9, I 2 =57%, and P=0.01; and Z=7.27, OR =14.67, 95% CI: 7.11-30.27, and P<0.01. After meta-analysis, the combined sensitivity was 72.26% (95% CI: 0.625-0.764) and the combined specificity was 95.35% (95% CI: 0.815-0.943). The area under the receiver operating characteristic curve (AUC) was 0.857. Conclusions:This meta-analysis confirmed that USE shows high sensitivity and specificity in diagnosing benign and malignant thyroid nodules, which could reduce the false negative rate (FNR) and false positive rate (FPR), showing high clinical diagnostic value.
Hospital-based transitional care can significantly reduce the postoperative complication in patients with enterostomy.
Osteosarcoma is a malignant tumor that develops from a mesenchymal cell line and is caused by gene–environment interactions. This study aimed to explore whether TIMP2/TIMP3 polymorphisms influenced the osteosarcoma risk. The expression of the TIMP2 and TIMP3 genes in osteosarcoma histiocytes was analyzed by immunohistochemistry. In this case-control study, which includes samples from 499 patients and 500 healthy controls, 10 single-nucleotide polymorphisms (SNPs) in TIMP2 and TIMP3 were selected. Furthermore, we used the Agena MassARRAY platform for genotyping. The statistical analysis was performed using χ 2 test/Fisher exact test, and logistic regression analysis. The immunohistochemistry results showed that the expression of TIMP2 is obvious higher in osteosarcoma histiocytes than in the normal histiocytes. The association study indicated that the allele of rs2277698 and rs4789936 were protective SNPs reducing the risk of osteosarcoma (odds ratios > 1, P < .05) by the χ 2 test. In the genetic model, logistic regression analyses revealed that the rs2277698 and rs4789936 were associated with decreasing the risk of osteosarcoma under the codominant model, dominant model, and log-additive model. Stratification analysis revealed that 2 SNPs (rs2277698 and rs4789936) were significantly associated with a reduced risk of osteosarcoma in allele and genetic model after stratification by gender or age (P < .05). In addition, the haplotype “Trs2277698Crs2009169Crs7342880” of TIMP2 was associated with decreasing the osteosarcoma risk. The “Ars9609634Trs11547635” of TIMP3 was associated with reducing the osteosarcoma risk. This finding shed new light on the high expression of TIMP2 polymorphisms may contribute to decreasing the osteosarcoma risk in Zhejiang populations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.