Insulin-like growth factor-binding protein-3 acts as a tumor suppressor that inhibits the PI3K/AKT signaling pathway due to blocking insulin growth factor-1 binding to its receptor. We hypothesized that insulin-like growth factor-binding protein-3 might be targeted by microRNA-125b and promote tumor invasion and poor outcome in non-small-cell lung cancer via activation of the PI3K/AKT signaling pathway. Real-time polymerase chain reaction and immunohistochemistry were performed to determine the level of microRNA-125b, insulin-like growth factor-binding protein-3 messenger RNA, and phosphorylated-AKT expression in 105 tumors from non-small-cell lung cancer patients. Low insulin-like growth factor-binding protein-3 messenger RNA levels and positive phosphorylated-AKT expression were more commonly found in patients with high microRNA-125b tumors than low microRNA-125b tumors. A poorer overall survival and relapse-free survival were observed in patients with high microRNA-125b tumors than low-microRNA-125b tumors in p53-mutated patients, but not in p53-wild-type patients. Mechanistically, microRNA-125b promotes invasion ability in p53-mutated cells via the PI3K/AKT activation by targeting of insulin-like growth factor-binding protein-3, but this effect was not observed in p53-wild-type cells. An increase in phosphorylated-AKT expression due to targeting of insulin-like growth factor-binding protein-3 by microRNA-125b was responsible for cell invasion in p53-mutated cells. In conclusion, the microRNA-125b level promotes invasive ability in p53-mutated cells via PI3K/AKT activation by targeting of insulin-like growth factor-binding protein-3, thereby resulting in p53-mutated non-small-cell lung cancer patients with poor outcomes.
LANGUAGE NOTE | Document text in English; abstract also in Chinese.The purpose of this paper was to explore the participant motivation of physical activity in leisure time for women. From the review of literatures on physical activity for women, it was ascertained that increased physical activity was highly associated with improved physical health and mental health. However, some researchers concluded some facts about women's participation in physical activity; (1) most adult women either don't do the recommended amount of physical activity or are completely inactive; (2) women are more inactive than men. Furthermore, recognizing and referring to the female participants' motivation of physical activity in leisure time, physical activity intervention programs would be designed more effectively and implemented more successfully.本文主要的目的是探討女性於閒暇時參與身體活動之動機。從相關文獻研究指出其主要身體活動參與動機因素如下:(1)人與人之間的轉向和調節 (2)個人能力 (3)逃離日常生活規範 (4)人與人之間正向發展 (5)轉移注意力 (6)人與人之間能力 (7)尋找異性朋友 (8)追求快樂感 (9)追求刺激 (10)追求冒險 (11)健康及幸福安寧感 (12)入迷 (13)社會互動 (14)創造力 (15)自我實現。
LANGUAGE NOTE | Document text in Chinese; abstract also in English. Schizophrenia is a mental disorder with barriers of thinking, perception and emotion. Most patients were unable to recognize what is real and degenerated of their social behavior functions. Physical activity/exercise had been proved its critical effects on reducing Schizophrenia symptoms in a safer way. It also provided patients a healthier life quality. However, few articles had mentioned and emphasized the effects of physical activity/exercise on Schizophrenia and offered relevant exercise prescription in Taiwan. This review article commenced with introduce of the symptoms and treatment of Schizophrenia followed by the effects of physical activity/exercise on Schizophrenia. Most important of all, exercise prescription and instructors’ special guideline were offered in the end of the review article. 思覺失調症是一種心理失常的疾病,患者在思考、知覺、情感等多方面出現障礙,其精神活動與現實有明顯的脫節,且大部分患者有明顯的社會功能不良或退化的現象。適當的運動已被證實可以安全有效減輕思覺失調症病患的症狀,進而增進患者的健康相關生活品質。然而國內少有文獻介紹思覺失調症身體活動/運動在預防及治療思覺失調症的效益,並為思覺失調症病患提供運動處方及特殊運動考量之建議。本文目的在於說明思覺失調症主要症狀與一般治療方式,進而探討身體活動/運動在預防及治療思覺失調症的效益,提供思覺失調症病患運動處方及其在運動特殊考量之建議。
LANGUAGE NOTE | Document text in Chinese; abstract also in English. Purposes: 1) Elderly females engaging different exercise programs (walking, low impact aerobic, chi-kung) and sedentary elderly women were compared on self-esteem and functional fitness; 2) The predictability of the 6 functional fitness variables to self-esteem was also tested. Methods: 256 elderly females (55-75 years old) were selected from each of the 3-exercised group (walking, low-impact aerobic, and chi-kung class) and sedentary group respectively. Measuring instruments included Functional Fitness Test and Rosenberg Self-Esteem Scale (RSES). One-way ANOVA was utilized to compare the three exercised-group of subjects on the overall self-esteem score (Rosenberg, 1965), and the multiple regression analysis was utilized to determine whether the 6 functional fitness predictors add to a linear function of self-esteem. Results: ‘Flexibility' was found to be significant (p < .05) predictor of self-esteem. Self-esteem , ‘BMI', ‘FLEX', ‘BAL', and ‘AGIL' of the physically active elderly women were significantly (p<.05) better than the non-exercised women. Furthermore, Self-esteem , ‘BMI', ‘FLEX', ‘BAL', ‘MUSCU', and ‘AGIL' scores of the elderly women of low impact aerobic exercised-group was significantly higher than those of the walking and Chi-kung group. However, no significant differences (p>.05) were found among the three groups in the mean‘ CARDIO' scores. Conclusion: Elderly females engaging in low impact aerobic have higher self-esteem and better functional fitness. Furthermore, Flexibility is the most important predictor of self-esteem in elderly females. 目的:比較從事步行、低衝擊有氧、及氣功,與久坐生活形態之中老年婦女,其自尊值和功能性體適能之差異。同時評估六項功能性體適能指標對於自尊值的預測能力。方法:以256位自願參與,年齡介於55歲到77歲之中老年婦女為受測者,其中49位為久坐生活形態的中老年婦女,85位從事氣功;35位從事步行,以及87位從事低衝擊有氧運動。本研究之測量包括功能性體適能測驗以及羅斯伯格自尊心之測量。結果:一、功能性體適能中柔軟度為自尊程度的顯著(p<.05)預測用變項;二、從事規律運動的中老年婦女之自尊值、身體質量指數、柔軟度、平衡、及敏捷性顯著(p<.05)高於沒有從事規律運動的中老年婦女;三、從事低衝擊有氧運動之中老年婦女的自尊程度和功能性體適能顯著(p<.05)高於從事步行、氣功的中老年婦女。結論:從事低衝擊有氧運動的參與者有較高的自尊及較好的功能性體適能狀況。除此之外,柔軟度是「自尊」之重要預測用變項。
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