The Coronavirus disease 2019 (COVID-19) has become one of the threats to the world. Computed tomography (CT) is an informative tool for the diagnosis of COVID-19 patients. Many deep learning approaches on CT images have been proposed and brought promising performance. However, due to the high complexity and non-transparency of deep models, the explanation of the diagnosis process is challenging, making it hard to evaluate whether such approaches are reliable. In this paper, we propose a visual interpretation architecture for the explanation of the deep learning models and apply the architecture in COVID-19 diagnosis. Our architecture designs a comprehensive interpretation about the deep model from different perspectives, including the training trends, diagnostic performance, learned features, feature extractors, the hidden layers, the support regions for diagnostic decision, and etc. With the interpretation architecture, researchers can make a comparison and explanation about the classification performance, gain insight into what the deep model learned from images, and obtain the supports for diagnostic decisions. Our deep model achieves the diagnostic result of 94.75%, 93.22%, 96.69%, 97.27%, and 91.88% in the criteria of accuracy, sensitivity, specificity, positive predictive value, and negative predictive value, which are 8.30%, 4.32%, 13.33%, 10.25%, and 6.19% higher than that of the compared traditional methods. The visualized features in 2-D and 3-D spaces provide the reasons for the superiority of our deep model. Our interpretation architecture would allow researchers to understand more about how and why deep models work, and can be used as interpretation solutions for any deep learning models based on convolutional neural network. It can also help deep learning methods to take a step forward in the clinical COVID-19 diagnosis field.
Many computer-aided diagnosis methods, especially ones with deep learning strategies, of liver cancers based on medical images have been proposed. However, most of such methods analyze the images under only one scale, and the deep learning models are always unexplainable. In this paper, we propose a deep learning-based multi-scale and multi-level fusing approach of CNNs for liver lesion diagnosis on magnetic resonance images, termed as MMF-CNN. We introduce a multi-scale representation strategy to encode both the local and semi-local complementary information of the images. To take advantage of the complementary information of multi-scale representations, we propose a multi-level fusion method to combine the information of both the feature level and the decision level hierarchically and generate a robust diagnostic classifier based on deep learning. We further explore the explanation of the diagnosis decision of the deep neural network through visualizing the areas of interest of the network. A new scoring method is designed to evaluate whether the attention maps can highlight the relevant radiological features. The explanation and visualization make the decision-making process of the deep neural network transparent for the clinicians. We apply our proposed approach to various state-of-the-art deep learning architectures. The experimental results demonstrate the effectiveness of our approach.
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