Background:
It has been reported the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2BAS1) might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to investigate the association between rs10757274 polymorphism and the risk of CAD.
Objectives:
The present study aimed to investigate the relationship between rs10757274 polymorphism and the risk of CAD.
Methods:
All studies of the rs10757274 SNP with CAD that were published between 2007 and 2018 were retrieved from the PubMed database. Meta-analysis was performed with Stata 14.0 software. The effect size of the rs10757274 SNP with CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).
Results:
Eleven studies including 52,209 subjects (cases: 7990, controls: 44,219) were included in the final data combination. Pooled overall analyses showed that rs10757274 (allele model: P < .001; dominant model: P < .001; recessive model: P < .001; Heterozygote codominant: P = .002; Homozygote codominant: P < .001) polymorphisms were significantly associated with the likelihood of CAD. Significant heterogeneity between individual studies appears in all 5 models. Further subgroup analyses revealed that rs10757274 polymorphisms were all significantly correlated with the likelihood of CAD and no heterogeneity were observed in West Asians.
Conclusions:
Our findings indicated that rs10757274 polymorphisms may serve as genetic biomarkers of CAD, especially in West Asians.
People’s demand for living space is getting higher. However, when people carry out interior decoration, they neglect the choice of environmental protection materials and various pollution problems. To improve people’s decoration and housing conditions, this paper studies the application of ecological energy-saving materials in intelligent building decoration. Firstly, the application status of intelligent building decoration materials is described. Then the advantages of ecological energy-saving decorative materials are analyzed. Finally, the application of the material in the wall and floor decoration was studied, and the sound insulation properties were tested. The comprehensive analysis shows that the application prospect of ecological energy-saving materials in intelligent building decoration is wide. According to the test results, the materials mentioned in the study exhibit effective characteristics for green building, indicating that energy saving materials have broad application prospects in this field.
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