C-Acetate can act as a probe of tissue metabolism through entry into catabolic or anabolic metabolic pathways as mediated by acetyl-coenzyme A. The uptake of 11 C-acetate in prostate cancer was investigated to determine whether this tracer has potential in tumor identification. Methods: Twenty-two patients with prostate cancer underwent PET after intravenous administration of 740 MBq 11 C-acetate. Eighteen of the 22 patients were also investigated with 18 F-FDG PET. Standardized uptake values (SUVs) for each tumor were investigated for tracer activity at 10-20 min after 11 C-acetate and 40-60 min after 18 F-FDG administration. Results: Adenocarcinoma of the prostate showed variable uptake of 11 C-acetate, with SUVs ranging from 3.27 to 9.87. In contrast, SUVs for 18 F-FDG ranged from 1.97 to 6.34. By visual inspection, 11 C-acetate accumulation in primary prostate tumors was positive in all patients, whereas 18 F-FDG accumulation was positive in only 15 of 18 patients. 11 C-Acetate PET in a patient with lymph node metastasis showed high intrapelvic accumulation corresponding to metastatic sites. Similarly, 2 patients with bone metastases were 11 C-acetate avid. Conclusion: 11 C-Acetate shows marked uptake in prostate cancer and is more sensitive in detection of prostate cancer than is 18 F-FDG PET. 11 C-Acetate represents a new tracer for detection of prostate cancer with PET, measuring radiopharmaceutical uptake pathways that are different from those measured by 18 F-FDG.
Although FDG-PET was not sensitive enough to detect prostate cancer in clinical use, it is suggested that glucose metabolism in prostate cancer tended to be higher in patients with tumors of advanced stages.
These results suggest the presence of at least two distinct alpha 1-adrenoceptor subtypes (presumably an alpha 1C subtype with a high affinity for prazosin and WB4101, and a putative alpha 1L subtype with a low affinity for the antagonists) in the human prostate, in which the latter subtype may be predominantly involved in the contractile response to noradrenaline.
These results suggest that at low doses tolterodine exerts an inhibitory effect on C-fiber bladder afferent nerves, thereby, improving BC during the storage phase.
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