. med. J3., 1968, 4, 430-431 : ummary: The effects of dextran 70 (Mw 70,000; Macrodex), heparin, dipyridamole (Persantin), and prostaglandin E1 on the behaviour of platelets were investigated at sites of endothelial trauma induced with a ruby biolaser in arterioles in the rabbit ear chamber. This technique has several advantages over previous methods of studying platelet activity.Dextran 70 (2 g./kg. body weight) caused a profound reduction in platelet activity four to six hours after its administration. Heparin (12 mg./kg. body weight) had no effect. The effect of dipyridamole (2.5 mg./kg. body weight) was profound immediately after its administration, but was transient. In preliminary experiments single intravenous injections of prostaglandin E1 (25 and 125 lmg./kg. body weight) had no detectable effect.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.