1 The replacement of 4-hydroxy-N-methyl piperidine (HO NMe) in 4-diphenylacetoxy-Nmethyl piperidine (4-DAMP) metho-bromide by 4-hydroxy-but-2-ynylamines (HOCH2C= CCH2NR2) reduces the affinity for muscarine-sensitive acetylcholine receptors in guinea-pig ileum and atria. It does not abolish selectivity. The tertiary amines are more active and more selective than the corresponding quaternary salts. 2 Analogous derivatives of 4-hydroxy-but-2-ynylamines which lack the ester group (i.e. substituted 4-hydroxymethyl-propynyl amines) are less active and less selective. The quaternary compounds are more active than the tertiary bases. 3 The diphenylcarbamyl ester of 4-hydroxy-N-methylpiperidine methobromide has less than onethousandth of the activity of the diphenylacetyl ester (4-DAMP methobromide) and is not selective. 4 Although 4-diphenylacetoxy-butynyl dimethylamine is only about one-hundredth as active as 4-DAMP methobromide it appears to have comparable selectivity. It is an interesting compound because it is a tertiary amine and should cross membranes.
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