Recebido em 4/5/05; aceito em 16/9/05; publicado na web em 31/3/06 THERMODYNAMIC FUNCTIONS RELATIVE TO THE TRANSFER OF KETOPROFEN FROM WATER TO SOME ORGANIC SYSTEMS. The thermodynamics of molal partitioning of ketoprofen (KTP) was studied in cyclohexane/buffer (CH/W), octanol/ buffer (ROH/W), and dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg lecithin (EGG/ W) liposome systems. In all cases the partition coefficients (K m o/w) were greater than unity; therefore the standard free energies of transfer were negative indicating affinity of KTP for organic media. The K m o/w values were approximately seventy-fold higher in the ROH/W system compared with the CH/W system. On the other hand, the K m o/w values were approximately ten or fifty-fold higher in the liposomes compared with the ROH/W system. In all cases, the standard enthalpies and entropies of transfer of KTP were positive indicating some degree of participation of the hydrophobic hydration on partitioning processes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.