The stratosphere can have a significant impact on winter surface weather on subseasonal to seasonal (S2S) timescales. This study evaluates the ability of current operational S2S prediction systems to capture two important links between the stratosphere and troposphere: (1) changes in probabilistic prediction skill in the extratropical stratosphere by precursors in the tropics and the extratropical troposphere and (2) changes in surface predictability in the extratropics after stratospheric weak and strong vortex events. Probabilistic skill exists for stratospheric events when including extratropical tropospheric precursors over the North Pacific and Eurasia, though only a limited set of models captures the Eurasian precursors. Tropical teleconnections such as the Madden‐Julian Oscillation, the Quasi‐Biennial Oscillation, and El Niño–Southern Oscillation increase the probabilistic skill of the polar vortex strength, though these are only captured by a limited set of models. At the surface, predictability is increased over the United States, Russia, and the Middle East for weak vortex events, but not for Europe, and the change in predictability is smaller for strong vortex events for all prediction systems. Prediction systems with poorly resolved stratospheric processes represent this skill to a lesser degree. Altogether, the analyses indicate that correctly simulating stratospheric variability and stratosphere‐troposphere dynamical coupling are critical elements for skillful S2S wintertime predictions.
The stratosphere has been identified as an important source of predictability for a range of processes on subseasonal to seasonal (S2S) time scales. Knowledge about S2S predictability within the stratosphere is however still limited. This study evaluates to what extent predictability in the extratropical stratosphere exists in hindcasts of operational prediction systems in the S2S database. The stratosphere is found to exhibit extended predictability as compared to the troposphere. Prediction systems with higher stratospheric skill tend to also exhibit higher skill in the troposphere. The analysis also includes an assessment of the predictability for stratospheric events, including early and midwinter sudden stratospheric warming events, strong vortex events, and extreme heat flux events for the Northern Hemisphere and final warming events for both hemispheres. Strong vortex events and final warming events exhibit higher levels of predictability as compared to sudden stratospheric warming events. In general, skill is limited to the deterministic range of 1 to 2 weeks. High‐top prediction systems overall exhibit higher stratospheric prediction skill as compared to their low‐top counterparts, pointing to the important role of stratospheric representation in S2S prediction models.
Extreme weather events have devastating impacts on human health, economic activities, ecosys tems, and infrastructure. It is therefore crucial to anticipate extremes and their impacts to allow for preparedness and emergency measures. There is indeed potential for probabilistic subseasonal prediction on timescales of several weeks for many extreme events. Here we provide an overview of subseasonal predictability for case studies of some of the most prominent extreme events across the globe using the ECMWF S2S prediction system: heatwaves, cold spells, heavy precipitation events, and tropical and extratropical cyclones. The considered heatwaves exhibit predictability on timescales of 3-4 weeks, while this timescale is 2-3 weeks for cold spells. Precipitation extremes are the least predictable among the considered case studies. Tropical cyclones, on the other hand, can exhibit probabilistic predictability on timescales of up to 3 weeks, which in the presented cases was aided by remote precursors such as the Madden-Julian Oscillation. For extratropical cyclones, lead times are found to be shorter. These case studies clearly illustrate the potential for event - dependent advance warnings for a wide range of extreme events. The subseasonal predictability of extreme events demonstrated here allows for an extension of warning horizons, provides advance information to impact modelers, and informs communities and stakeholders affected by the impacts of extreme weather events.
Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative bacteria. Moreover, TLR4 has been suggested to play a role in the phagocytosis of Gram-negative bacteria, but the mechanisms remain unclear. Here we have used primary human macrophages and engineered THP-1 monocytes to show that the TLR4 sorting adapter, TRAM, is instrumental for phagocytosis of
Escherichia coli
as well as
Staphylococcus aureus
. We find that TRAM forms a complex with Rab11 family interacting protein 2 (FIP2) that is recruited to the phagocytic cups of
E
.
coli
. This promotes activation of the actin-regulatory GTPases Rac1 and Cdc42. Our results show that FIP2 guided TRAM recruitment orchestrates actin remodelling and IRF3 activation, two events that are both required for phagocytosis of Gram-negative bacteria.
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