L-2-Amino-4-(2-aminoethoxy)-trans-3-butenoic acid was isolated from a fermentation broth of an unidentified species of Streptomyces, X-11,085. This substance inhibited the growth of Streptomyces cellulosae in a chemically defined minimal medium. The growth inhibition was reversed noncompetitively by L-cysteine and competitively by L-lysine, L-arginine and L-ornithine. An amino acid antimetabolite which inhibited the growth of Streptomyces cellulosae ATCC-3313* on a chemically defined medium2) was discovered in a fermentation broth of an unidentified Streptomyces sp. X-11,085 (deposited with the Northern Regional Research Laboratories under THE JOURNAL OF ANTIBIOTICS APR.
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