PROPOsE: To compare the postoperative analgesic effects of electroacupuncture, morphine or sham acupuncture in dogs undergoing mastectomy.METHOds: Thirty client-owed dogs undergoing to mastectomy were randomly assigned to three groups of 10 animals each and received either morphine (T-M), the electroacupuncture (T-EA) or sham procedure (T-Sham). Pre-anesthetic medication was acepromazine (0.05 mg kg -1 , IM). Anesthesia was induced with propofol (4 to 5 mg kg -1 , IV) and maintained with isoflurane. Postoperatively pain degree was assessed using a numerical rating scale. Dogs were scored at 1, 3, 6 and 12 hours post-extubation. If the pain score was ≥6, supplemental morphine was administered. Serum cortisol concentration was measured before pre-anesthetic medication, at 45 minutes after the anesthetic induction, and at 1, 3 and 6 hours post-extubation. REsuLTs:The pain score did not differ among the treatments, but rescue analgesia was lower in the T-EA group (2 of 10 dogs), when compared with T-Sham (6 of 10 dogs) and T-M (6 of 10 dogs) groups. Serum cortisol concentration did not differ among the treatments.CONCLusION: Electroacupuncture reduces the postoperative analgesic requirement and promotes satisfactory analgesia in dogs undergoing mastectomy.

PURPOSE:To evaluate the analgesic and neuroendocrine effects of electroanalgesia in dogs undergoing ovariohysterectomy. METHODS:Eighteen dogs were randomly distributed to three groups of six animals each and received either electrical stimuli at acupuncture points (EA), at peri-incisional dermatomes (DER) and at both acupuncture points and peri-incisional dermatomes (EAD).Pre-anesthetic medication was acepromazine (0.05mg kg -1 , IV). Anesthesia was induced with propofol (4 to 5mg kg -1 , IV) and maintained with isoflurane. Postoperatively pain degree was measured using a numerical rating scale. Dogs were scored at 1, 3, 6, 12 and 24 hours postoperative. If the pain score was ≥6, supplemental morphine (0.5mg kg -1 , IM) was administered. Serum cortisol concentration was measured before pre-anesthetic medication (basal), and at 1, 12 and 24 hours postoperative. RESULTS:EA and EAD-treated dogs had lower pain scores than DER treated dogs one hour postoperatively. Fewer EA and EADtreated dogs required rescue analgesia. Serum cortisol did not differ among treatments. CONCLUSION:Preoperative application of electrical stimuli to acupuncture points isolated or in combination with periincisional dermatomes provides a reduced postoperative opioid requirement and promotes an effective analgesia in dogs undergoing ovariohyterectomy.Key words: Electroacupuncture. Analgesia. Ovary. Hysterectomy. Salpingectomy. Dogs. RESUMO OBJETIVO:Avaliar os efeitos analgésicos e neuroendócrinos da eletroanalgesia em cadelas encaminhadas para ovariossalpingohisterectomia. MÉTODOS:Foram avaliadas 18 cadelas, distribuídas aleatoriamente em três tratamentos de seis animais cada: aplicação de estímulo elétrico em pontos de acupuntura (EA), em dermátomos periincisionais (DER) e em pontos de acupuntura associados aos dermátomos periincisionais (EAD). Todos os animais foram tranquilizados com acepromazina (0,05mg kg -1 , IV), seguindo-se a indução com propofol (4 a 5mg kg -1 , IV) e manutenção anestésica com isofluorano. O grau de analgesia foi avaliado 1, 3, 6, 12 e 24 horas após a cirurgia mediante escala descritiva numérica. Animais com escores ≥6 receberam analgesia de resgate com morfina (0,5mg kg -1 , IM). A concentração sérica de cortisol foi avaliada antes da tranquilização, 1, 12 e 24 horas após a cirurgia. RESULTADOS:Escores inferiores de dor foram observados nos tratamentos EA e EAD em relação ao DER na primeira hora pós-operatória. A analgesia de resgate foi menos requerida nos animais dos tratamentos EA e EAD. O cortisol não diferiu entre os tratamentos.CONCLUSÃO: A eletroestimulação de acupontos isolados ou associados aos dermátomos periincisionais reduz o requerimento pós-operatório de opioides, bem como confere efetiva analgesia para cadelas submetidas à ovariossalpingohisterectomia.

BackgroundThe objective of this study was to evaluate the effectiveness of various linseed oil (LO) preparations (oral, topical, oral and topical combined) in treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty male New Zealand white rabbits were divided into four groups: group C (control), group OLO (oral LO), group TLO (topical LO), and group OTLO (oral and topical LO). The animals were evaluated weekly using Schirmer's tear test (STT), fluorescein test (FT), and Rose Bengal test (RBT) and were euthanized at the end of the experiment for histopathological analysis.FindingsThere were significant improvements in the parameters analyzed (STT, FT, and RBT) and in the histopathological finding in all of the groups using LO.ConclusionsThe analyzed results demonstrate that LO, administered orally or topically, was effective in treating experimentally induced KCS in rabbits, although combined oral and topical LO did not show additional benefits greater than those with a single route of administration.

RESUMOInvestigou-se o efeito da lidocaína isolada ou associada ao fentanil na anestesia epidural, para realização de ováriossalpingo-histerectomia. Dezoito cadelas foram tranqüilizadas com acepromazina, seguindo-se indução anestésica com propofol, para a realização da punção lombossacra. Os animais foram distribuídos em dois grupos: o grupo GL recebeu lidocaína (8,5mg/kg) e o GLF fentanil (5µg/kg) associado à lidocaína (6,5mg/kg). Mensuraram-se as freqüências cardíaca (FC) e respiratória (FR), pressão arterial sistólica (PAS), variáveis hemogasométricas, concentração sérica de cortisol, necessidade de complementação anestésica com propofol durante a cirurgia, temperatura retal (T), período de latência e duração do bloqueio anestésico. Foi observada redução na FC, FR e PAS no GL e GLF, porém esses parâmetros mantiveram-se dentro dos limites fisiológicos. Para ambos os grupos, a concentração sérica de cortisol manteve-se estável após a cirurgia. Complementação anestésica foi necessária em 40% e 75% dos animais do GLF e GL, respectivamente. Conclui-se que ambos os protocolos foram suficientes para inibir a elevação sérica do cortisol, e resultaram em alterações mínimas cardiorrespiratórias, e que a complementação anestésica foi necessária.

PURPOSE: To compare the postoperative analgesic effects of the extradural tramadol or morphine in female dogs undergoing ovariohysterectomy. METHODS: Sixteen female dogs were randomly assigned to two groups of eight animals each and received morphine (0.1mg kg-1 M group) or tramadol (2mg kg-1 T group). The pre-anesthetic medication was intravenously (iv) acepromazine (0.05mg kg-1). Anesthesia was induced with propofol (4mg kg-1iv) and maintained with isoflurane. The degree of analgesia was evaluated using a numerical rating scale that included physiologic and behavior variables. Dogs were scored at one, three, six and 12 hours after surgery by one blinded observer. Dogs were treated with morphine (0.5mg kg-1) if their scores were >6. Serum cortisol was measured before the pre-anesthetic medication was administered (basal), at the time of the ovarian pedicle clamping (T0), and at 1 (T1), 6 (T6) and 12 (T12) hours postoperative. RESULTS: The pain score did not differ between morphine and tramadol treatments. Rescue analgesia was administered to one dog in the T treatment group. Serum cortisol did not differ between treatments. CONCLUSION: The extradural administration of morphine or tramadol is a safe and effective method of inducing analgesia in female dogs undergoing ovariohyterectomy.