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Background: Children's home-related injuries are considered a community health problem. They are the leading cause of death for children under the age of five years. Thousands of children are permanently injured every year as a result of these incidents. The majority of these incidents can be avoided by raising awareness and improving home climate and product safety. Objectives: To assess the knowledge and attitude of mothers about home-related injuries and its predisposing factors for children less than five years old. Methods: This cross-sectional study was carried out from 1 st of March to the end of May 2019 among 628 mothers attending outpatient pediatric clinics (OPC), Beni-Suef University Hospital, for follow-up visits of their children. A 3-part structured questionnaire was used aiming to analyze the demographic data and measure the percentage and types of home injuries as well as maternal knowledge and attitudes about causes of home accidents in children. Results: Home-related injuries among children under the age of 5 years were 42.4% amongst which cut wounds representing 51.1% of the cases. Regarding the maternal knowledge about first aid measures, 16.6% of the mothers were not knowledgeable. Maternal knowledge scores revealed that 78% of respondents perceived the risk and 8.6% did not. Maternal attitude scores revealed a 92.7% indifferent attitude score and 0.6% positive attitude score. Regression analysis showed that mother's attitude towards home injuries was significantly affected by her educational level, occupation (being a working mother or not), and reading books about the first aid (P<0.05). Conclusions: Mothers perceived the risk about childhood home-related injuries and their attitude scores were indifferent.