No abstract

Deep learning methods, and in particular convolutional neural networks (CNNs), have led to an enormous breakthrough in a wide range of computer vision tasks, primarily by using large-scale annotated datasets. However, obtaining such datasets in the medical domain remains a challenge. In this paper, we present methods for generating synthetic medical images using recently presented deep learning Generative Adversarial Networks (GANs). Furthermore, we show that generated medical images can be used for synthetic data augmentation, and improve the performance of CNN for medical image classification. Our novel method is demonstrated on a limited dataset of computed tomography (CT) images of 182 liver lesions (53 cysts, 64 metastases and 65 hemangiomas). We first exploit GAN architectures for synthesizing high quality liver lesion ROIs. Then we present a novel scheme for liver lesion classification using CNN. Finally, we train the CNN using classic data augmentation and our synthetic data augmentation and compare performance. In addition, we explore the quality of our synthesized examples using visualization and expert assessment. The classification performance using only classic data augmentation yielded 78.6% sensitivity and 88.4% specificity. By adding the synthetic data augmentation the results increased to 85.7% sensitivity and 92.4% specificity. We believe that this approach to synthetic data augmentation can generalize to other medical classification applications and thus support radiologists' efforts to improve diagnosis.

ÐRetrieving images from large and varied collections using image content as a key is a challenging and important problem. We present a new image representation that provides a transformation from the raw pixel data to a small set of image regions that are coherent in color and texture. This ªBlobworldº representation is created by clustering pixels in a joint color-texture-position feature space. The segmentation algorithm is fully automatic and has been run on a collection of 10,000 natural images. We describe a system that uses the Blobworld representation to retrieve images from this collection. An important aspect of the system is that the user is allowed to view the internal representation of the submitted image and the query results. Similar systems do not offer the user this view into the workings of the system; consequently, query results from these systems can be inexplicable, despite the availability of knobs for adjusting the similarity metrics. By finding image regions that roughly correspond to objects, we allow querying at the level of objects rather than global image properties. We present results indicating that querying for images using Blobworld produces higher precision than does querying using color and texture histograms of the entire image in cases where the image contains distinctive objects.

In this paper, we present a data augmentation method that generates synthetic medical images using Generative Adversarial Networks (GANs). We propose a training scheme that first uses classical data augmentation to enlarge the training set and then further enlarges the data size and its diversity by applying GAN techniques for synthetic data augmentation. Our method is demonstrated on a limited dataset of computed tomography (CT) images of 182 liver lesions (53 cysts, 64 metastases and 65 hemangiomas). The classification performance using only classic data augmentation yielded 78.6% sensitivity and 88.4% specificity. By adding the synthetic data augmentation the results significantly increased to 85.7% sensitivity and 92.4% specificity.

No abstract