Purpose: The current study aimed at assessing the effect of oral sildenafil citrate on postobstructive diuresis and urinary electrolyte changes after the management of bilateral ureteral obstruction (BUO). Methods: Twenty-eight adult Munich-Wistar male rats were subjected to the surgery-induced BUO for 24 hours. In intervention group (n = 14) sildenafil citrate 200 mg/kg food was administered from the operation day for 72 hours, while in control group (n = 14) no drug was used. Daily urinary volume, urine sodium (mEq/day), potassium (mEq/day), and osmolality (mOsm/kg H2O) were measured on the day before BUO and for 2 days after BUO release. Results: In comparison to the control group, postobstructive diuresis was significantly lower in the sildenafil group (P value < 0.001), while urinary sodium and osmolality were both preserved better in this group (P value < 0.001); however, there were no significant difference in potassium level between the groups (P value = 0.285). Conclusions: Oral sildenafil citrate significantly decreased postobstructive diuresis and preserved urine sodium and osmolality near normal. These 2 effects mean a better preservation of renal function, while preventing massive postobstructive diuresis.
Background: Obstructive uropathy disease is a potentially lethal disease caused by the urination disorder, which is of great importance to proper treatment. Objectives: Based on the mentioned section, the aim was to compare the results and complications of percutaneous nephrostomy with hemodialysis in correcting water and electrolyte disorders in patients with obstructive uropathy. Methods: In this as a clinical trial study, thirty patients with obstructive uropathy were considered as the study group. Patients were randomly divided into hemodialysis and PCN (percutaneous nephrostomy) groups. In both groups, BUN/Cr, Na, and K were measured every six hours. The variables T1 (time to preparation for action), T2 (time to clearance), T3 (total hospitalization time), pain score, satisfaction rate, and complications in both groups were compared. Finally, the data were analyzed using the SPSS software. Results: Results show that T1 in both PCN and hemodialysis groups was not significantly different. However, T2 and T3 in the PCN group had a significant decrease compared to the hemodialysis group, also the satisfaction rate in patients with PCN was better than hemodialysis. Concentration of potassium and creatinine in the PCN method decreased more than hemodialysis. However, there was no significant difference in the trend of reduction of other indicators such as sodium concentration, systolic, and diastolic blood pressure in both methods. Conclusions: PCN can be an alternative, appropriate, cheap, and less complicated method for patients with obstructive uropathy.
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