A high-performance ultraviolet photodetector based on a thin layer DPPT-TT organic material is experimentally demonstrated. The high absorption of DPPT-TT in the ultraviolet band is attributed to the foundation for a high-performance ultraviolet detector. The device's responsivity can be improved by adequately designing the hole-blocking layer HfO2 and the stepped structure at the bottom contact. Due to the self-filtering and optical trapping structure, the device achieves external quantum efficiency above 100%, even with a thin absorption layer (around 50 nm). The maximum spectral responsivity of the device is 383 A/W, and the corresponding maximum specific detection rate is about 2.79 × 1012 at a bias voltage of 0.5 V. Our results advocate that the thin organic ultraviolet photodetector promises excellent potential in low-cost ultraviolet-visible light detection and imaging applications.
Almost all patients with advanced prostate cancer (PCa) will eventually progress to incurable castration-resistant PCa (CRPC) if endocrine therapy fails. Therefore, identifying potential cellular targets is critical for the development of novel and effective treatments for CRPC. Based on the investigation of the molecular mechanism of ATN-224, an anticancer drug in clinical trials, in CRPC DU145 cells, the antioxidant enzyme catalase (CAT) has been recognized as an actionable CRPC therapeutic target, and the modulation of intracellular redox state through CAT inhibition has great potential for CRPC treatment. After systematic design and synthesis, the benzaldehyde thiosemicarbazone derivative BT-1 is shown to be effective CAT inhibitor in DU145 cells. This inhibition induces the significant increase of both superoxides (O 2 •−) and H 2 O 2 levels in DU145 cells. Finally, the dual pro-oxidant effect of BT-1 is demonstrated to lead to apoptosis as well as cell-cycle arrest in DU145 cells, effectively reducing CRPC tumors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.