A luminescent
terbium metal–organic framework [Tb(HPIA–)(PIA2–)(H2O)2] (Tb-MOF),
synthesized by a lanthanide metal ion (Tb3+) and nitric
heterocyclic carboxylic acid ligands H2PIA
(H2PIA = 5-(1H-pyrazol-3-yl)isophthalic-acid),
was structurally characterized as a three-dimensional skeleton structure
in which layered coordination frameworks are connected by hydrogen
bonds. Based on the antenna effect, Tb-MOF can emit bright green fluorescence
under 254 nm excitation, and the fluorescence emission presents excellent
durability in aqueous solutions among a wide pH range. Moreover, the
structure of Tb-MOF also possesses outstanding thermal stabilities.
In some ways, PO43– and its derivatives
are thought to be a kind of pollutant ion causing series environmental
and health problems. The as-synthesized Tb-MOF exhibits prominent
selectivity and remarkable sensitivity for detecting PO43– as an easy-to-use fluorescent probe with low
detection limit, fast response, and wide detection range. Therefore,
Tb-MOF has significant applications in the fields of human health
and environmental monitoring.
The gut microbiota is now known as a key factor in mammalian physiology and health. Our understanding of the gut microbial communities and their effects on ecology and evolution of their hosts is extremely limited in bats which represent the second largest mammalian order. In the current study, gut microbiota of three sampling sources (small intestine, large intestine, and feces) were characterized in two sympatric and insectivorous bats (Rhinolophus sinicus and Myotis altarium) by high-throughput sequencing of the V3-V4 region of the 16S rRNA gene. Combining with published studies, this work reveals that Gammaproteobacteria may be a dominant class in the whole Chiroptera and Fusobacteria is less observed in bats although it has been proven to be dominant in other mammals. Our results reveal that the sampling source influences alpha diversity of the microbial community in both studied species although no significant variations of beta diversity were observed, which support that fecal samples cannot be used as a proxy of the microbiota in other gut regions in wild animals.
Gold nanorods, mesoporous silica, gadolinia, folic acid, and polyethylene glycol (PEG) derivatives have been investigated due to their own advantages in cancer theranostics. However, it remains a great challenge to assemble these components into a stable unity with the diverse and enhanced functionality for more potential applications. Herein, as inspired by the first-principles calculation, a highly stable and safe all-in-one nanoprobe is fabricated via a novel nanoassembly strategy. Multiscale calculations were performed to address the atomistic bonding of a nanoprobe, heat necrosis of a tumor adjacent to the vasculature, and thermal diffusion in a photothermal circumstance, respectively. The nanoprobe gains an 8-fold increase in magnetic resonance imaging (MRI) relaxivity compared to the clinical gadolinium diethylenetriaminepentaacetate, achieving a significant MRI signal in vivo. Conjugated with folate-PEG, the nanoprobe can be effectively absorbed by tumoral cells, obtaining a vivid two-photon cell imaging. A specific multisite scheme for photothermal therapy of a solid tumor is proposed to improve low photothermal efficacy caused by thermal diffusion in a large tumor, leading to the successful cure of the mice with xenograft tumor sized 10−12 mm. In vitro and in vivo toxicity, long-term excretion data, and the recovery of the treated mice demonstrate that the theranostic nanoprobe possesses good biocompatibility and metabolism efficacy.
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