Objective: This study aimed to compare the diagnostic performance of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in the patients with various oncological and non-oncological lesions.Patients and Methods: A total of 123 patients underwent contemporaneous 68 Ga-FAPI-04 and 18 F-FDG PET/CT were included in this prospective study. The maximum standard uptake value (SUVmax) was measured to compare oncological and non-oncological lesion uptake. The sensitivity, speci city, predictive values and accuracy of 18 F-FDG and 68 Ga-FAPI-04 PET/CT for detecting primary, metastatic, and non-oncological lesions were calculated and compared to evaluate the diagnostic e cacy.Results: The study subjects consisted of 123 patients (69 men and 54 women; mean age: 56.11±11.94). A total of 84 patients with 88 solid primary malignant tumors, 58 patients with 376 nodal metastases, 43 patients with 406 distant metastases, 8 patients with hematological neoplasms and 52 patients with 145 non-oncological lesions and benign tumors were detected. 68 Ga-FAPI-04 PET/CT demonstrated a signi cantly higher uptake and detection rate for the primary (SUVmax: 10.98±5.83 vs. 8.36±6.43, p 0.001; X 2 =0.538, p=0.021), nodal (SUVmax: 10.50±5.98 vs. 8.20±6.29, p=0.011; X 2 =2.067, p 0.001) and distant metastatic lesions (SUVmax: 6.74±4.83 vs. 9.64±6.45; p 0.001; X 2 =4.897, p 0.001) of solid tumor than did 18 F-FDG PET/CT. 68 Ga-FAPI-04 PET/CT demonstrated a lower activity (SUVmax: 6.84±4.67 vs. 13.09±7.29, p 0.001) and detection rate (X 2 =5.166, p 0.001) for multiple myeloma and lymphoma compared to 18 F-FDG PET/CT. 68 Ga-FAPI-04 and 18 F-FDG PET/CT PET/CT demonstrated a comparative diagnostic e cacy (SUVmax: 6.40±3.95 vs. 5.74±15.78, p = 0.729; X 2 = 9.460, p = 0.007) for nononcological lesion and benign tumor detection.Conclusions: Except for myeloma and lymphoma, 68 Ga-FAPI-04 PET/CT showed a superior diagnostic e cacy for detecting various primary and metastatic lesions than 18 F-FDG PET/CT. A comparative diagnostic utility for nononcological lesion detection was obtained with both tracers. 68 Ga-FAPI-04 could be used as a broad-spectrum tumor and in ammatory imaging agent in the clinical especially for various solid tumors and non-oncological lesions.
Renal brosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolong the survival of patients. Renal puncture examination represents the gold standard examination method for renal brosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [ 68 Ga]Ga-broblast activation protein inhibitor (FAPI)-04, which speci cally images broblast activation protein (FAP) expression for renal brosis.
MethodsAll patients underwent renal puncture before receiving [ 68 Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [ 68 Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations, and the data obtained were analyzed.
ResultsThe [ 68 Ga]Ga-FAPI-04 PET/CT examination results showed that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe brosis was 3.92±1.50, 5.98±1.6, and 7.67±2.23, respectively.
ConclusionCompared with renal puncture examination, non-invasive imaging of FAP expression through [ 68 Ga]Ga-FAPI-04 PET/CT can quickly show the patient's bilateral kidney condition with high sensitivity. This can facilitate the evaluation of the patient's disease progression, diagnosis, and the development of a treatment plan.
This work proposed a straightforward and sustainable strategy to synthesize a Ag/ZnO decorated cellulose nanocomposite. First, zincate was introduced into an aqueous cellulose−NaOH/urea dope to enhance the solution stability. Second, AgNO 3 was directly added into the cellulose dope without gelation, and then was reduced into Ag NPs by cellulose chain. Finally, zincate transformed into ZnO via biomimetic mineralization along with the regeneration of the cellulose dope, and an Ag/ZnO decorated cellulose nanocomposite film was synthesized. The Ag NPs with a mean diameter of 16.5 nm were well dispersed in the cellulose matrix, and some were doped on the surface of the embedded ZnO crystal. With increase of the Ag loading, the nanocomposite film showed more rapid sterilization for Escherichia coli than Staphylococcus aureus, and complete eradication could be achieved within 3 h for both bacteria. This simple and environmental friendly method hopefully provided new routes for large-scale production of antibacterial cellulose-based nanohybrids in industry.
Studies on landslides by the 2008 Wenchuan earthquake showed that the topography is of great importance in amplifying the seismic shaking. The present study carried out experiments on rock slopes by means of a shaking table. The recorded Wenchuan earthquake waves are scaled to excite the model slopes. Measurements from accelerometers installed on free surface of the model slope simulating high-strength rocks are analyzed, with much effort on acceleration responses to both horizontal and vertical components of seismic shaking. It is found that the amplification factor of peak horizontal acceleration (PHA) is increasing with elevation of the model slope, though the upper and lower halves of the slope exhibit different increasing patterns. The amplification factor of peak vertical acceleration (PVA) exhibits a lying S-shaped changing trend with the elevation, indicating attenuations of PVAs at the toe and top of a slope. In addition, the XZ-direction shaking produces a horizontal and vertical response stronger than X-direction and Z-direction shaking alone. Both PHA and PVA increase with the excitation intensity. However, the corresponding amplification factors generally decrease, indicating the acceleration response of a slope weakens with the excitation intensity of shaking. Finally the statistic of ratio of PVA to PHA indicates that 85% of the slope height, especially the upper middle part, is likely subject to PVAs greater than or equal to 2=3 of PHA and 32% of the slope height to PVAs greater than or equal to PHA. This indicates the nonignorable role of PVA in responses of a slope to an earthquake and necessity of considering during design work.
PurposeRenal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolong the survival of patients. Renal puncture examination represents the gold standard examination method for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [68Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis.MethodsAll patients underwent renal puncture before receiving [68Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [68Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations, and the data obtained were analyzed.ResultsThe [68Ga]Ga-FAPI-04 PET/CT examination results showed that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92±1.50, 5.98±1.6, and 7.67±2.23, respectively.ConclusionCompared with renal puncture examination, non-invasive imaging of FAP expression through [68Ga]Ga-FAPI-04 PET/CT can quickly show the patient’s bilateral kidney condition with high sensitivity. This can facilitate the evaluation of the patient’s disease progression, diagnosis, and the development of a treatment plan.
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