.
Significance
X-ray Cherenkov–luminescence tomography (XCLT) produces fast emission data from megavoltage (MV) x-ray scanning, in which the excitation location of molecules within tissue is reconstructed. However standard filtered backprojection (FBP) algorithms for XCLT sinogram reconstruction can suffer from insufficient data due to dose limitations, so there are limits in the reconstruction quality with some artifacts. We report a deep learning algorithm for XCLT with high image quality and improved quantitative accuracy.
Aim
To directly reconstruct the distribution of emission quantum yield for x-ray Cherenkov-luminescence tomography, we proposed a three-component deep learning algorithm that includes a Swin transformer, convolution neural network, and locality module model.
Approach
A data-to-image model x-ray Cherenkov-luminescence tomography is developed based on a Swin transformer, which is used to extract pixel-level prior information from the sinogram domain. Meanwhile, a convolutional neural network structure is deployed to transform the extracted pixel information from the sinogram domain to the image domain. Finally, a locality module is designed between the encoder and decoder connection structures for delivering features. Its performance was validated with simulation, physical phantom, and
in vivo
experiments.
Results
This approach can better deal with the limits to data than conventional FBP methods. The method was validated with numerical and physical phantom experiments, with results showing that it improved the reconstruction performance mean square error (
), peak signal-to-noise ratio (
), and Pearson correlation (
) compared with the FBP algorithm. The Swin-CNN also achieved a 32.1% improvement in PSNR over the deep learning method AUTOMAP.
Conclusions
This study shows that the three-component deep learning algorithm provides an effective reconstruction method for x-ray Cherenkov-luminescence tomography.
Aperture Masking Interferometry (AMI) is one of the high-resolution astronomical image observation technologies. It is also an important research way to the Optical Aperture Synthesis (OAS). The theory of OAS is simply introduced and AMI simulation method is raised. The mathematics model is built and the interferogram fringes are got. The aperture mask u-v coverage is discussed and one image reconstruction method is done. The reconstructed image result is got with CLEAN method. Shortcoming of this work is also referred and the future research work is mentioned at last.
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