Eye tracking is a useful technique for detecting autism spectrum disorder (ASD). One of the most important aspects of good learning is the ability to have atypical visual attention. The eye-tracking technique provides useful information about children’s visual behaviour for early and accurate diagnosis. It works by scanning the paths of the eyes to extract a sequence of eye projection points on the image to analyse the behaviour of children with autism. In this study, three artificial-intelligence techniques were developed, namely, machine learning, deep learning, and a hybrid technique between them, for early diagnosis of autism. The first technique, neural networks [feedforward neural networks (FFNNs) and artificial neural networks (ANNs)], is based on feature classification extracted by a hybrid method between local binary pattern (LBP) and grey level co-occurrence matrix (GLCM) algorithms. This technique achieved a high accuracy of 99.8% for FFNNs and ANNs. The second technique used a pre-trained convolutional neural network (CNN) model, such as GoogleNet and ResNet-18, on the basis of deep feature map extraction. The GoogleNet and ResNet-18 models achieved high performances of 93.6% and 97.6%, respectively. The third technique used the hybrid method between deep learning (GoogleNet and ResNet-18) and machine learning (SVM), called GoogleNet + SVM and ResNet-18 + SVM. This technique depends on two blocks. The first block used CNN to extract deep feature maps, whilst the second block used SVM to classify the features extracted from the first block. This technique proved its high diagnostic ability, achieving accuracies of 95.5% and 94.5% for GoogleNet + SVM and ResNet-18 + SVM, respectively.

An infectious disease called tuberculosis (TB) exhibits pneumonia-like symptoms and traits. One of the most important methods for identifying and diagnosing pneumonia and tuberculosis is X-ray imaging. However, early discrimination is difficult for radiologists and doctors because of the similarities between pneumonia and tuberculosis. As a result, patients do not receive the proper care, which in turn does not prevent the disease from spreading. The goal of this study is to extract hybrid features using a variety of techniques in order to achieve promising results in differentiating between pneumonia and tuberculosis. In this study, several approaches for early identification and distinguishing tuberculosis from pneumonia were suggested. The first proposed system for differentiating between pneumonia and tuberculosis uses hybrid techniques, VGG16 + support vector machine (SVM) and ResNet18 + SVM. The second proposed system for distinguishing between pneumonia and tuberculosis uses an artificial neural network (ANN) based on integrating features of VGG16 and ResNet18, before and after reducing the high dimensions using the principal component analysis (PCA) method. The third proposed system for distinguishing between pneumonia and tuberculosis uses ANN based on integrating features of VGG16 and ResNet18 separately with handcrafted features extracted by local binary pattern (LBP), discrete wavelet transform (DWT) and gray level co-occurrence matrix (GLCM) algorithms. All the proposed systems have achieved superior results in the early differentiation between pneumonia and tuberculosis. An ANN based on the features of VGG16 with LBP, DWT and GLCM (LDG) reached an accuracy of 99.6%, sensitivity of 99.17%, specificity of 99.42%, precision of 99.63%, and an AUC of 99.58%.

Parkinson’s disease (PD) is a neurodegenerative condition generated by the dysfunction of brain cells and their 60–80% inability to produce dopamine, an organic chemical responsible for controlling a person’s movement. This condition causes PD symptoms to appear. Diagnosis involves many physical and psychological tests and specialist examinations of the patient’s nervous system, which causes several issues. The methodology method of early diagnosis of PD is based on analysing voice disorders. This method extracts a set of features from a recording of the person’s voice. Then machine-learning (ML) methods are used to analyse and diagnose the recorded voice to distinguish Parkinson’s cases from healthy ones. This paper proposes novel techniques to optimize the techniques for early diagnosis of PD by evaluating selected features and hyperparameter tuning of ML algorithms for diagnosing PD based on voice disorders. The dataset was balanced by the synthetic minority oversampling technique (SMOTE) and features were arranged according to their contribution to the target characteristic by the recursive feature elimination (RFE) algorithm. We applied two algorithms, t-distributed stochastic neighbour embedding (t-SNE) and principal component analysis (PCA), to reduce the dimensions of the dataset. Both t-SNE and PCA finally fed the resulting features into the classifiers support-vector machine (SVM), K-nearest neighbours (KNN), decision tree (DT), random forest (RF), and multilayer perception (MLP). Experimental results proved that the proposed techniques were superior to existing studies in which RF with the t-SNE algorithm yielded an accuracy of 97%, precision of 96.50%, recall of 94%, and F1-score of 95%. In addition, MLP with the PCA algorithm yielded an accuracy of 98%, precision of 97.66%, recall of 96%, and F1-score of 96.66%.

Epilepsy is a neurological disorder in the activity of brain cells that leads to seizures. An electroencephalogram (EEG) can detect seizures as it contains physiological information of the neural activity of the brain. However, visual examination of EEG by experts is time consuming, and their diagnoses may even contradict each other. Thus, an automated computer-aided diagnosis for EEG diagnostics is necessary. Therefore, this paper proposes an effective approach for the early detection of epilepsy. The proposed approach involves the extraction of important features and classification. First, signal components are decomposed to extract the features via the discrete wavelet transform (DWT) method. Principal component analysis (PCA) and the t-distributed stochastic neighbor embedding (t-SNE) algorithm were applied to reduce the dimensions and focus on the most important features. Subsequently, K-means clustering + PCA and K-means clustering + t-SNE were used to divide the dataset into subgroups to reduce the dimensions and focus on the most important representative features of epilepsy. The features extracted from these steps were fed to extreme gradient boosting, K-nearest neighbors (K-NN), decision tree (DT), random forest (RF) and multilayer perceptron (MLP) classifiers. The experimental results demonstrated that the proposed approach provides superior results to those of existing studies. During the testing phase, the RF classifier with DWT and PCA achieved an accuracy of 97.96%, precision of 99.1%, recall of 94.41% and F1 score of 97.41%. Moreover, the RF classifier with DWT and t-SNE attained an accuracy of 98.09%, precision of 99.1%, recall of 93.9% and F1 score of 96.21%. In comparison, the MLP classifier with PCA + K-means reached an accuracy of 98.98%, precision of 99.16%, recall of 95.69% and F1 score of 97.4%.

Melanoma is a cancer that threatens life and leads to death. Effective detection of skin lesion types by images is a challenging task. Dermoscopy is an effective technique for detecting skin lesions. Early diagnosis of skin cancer is essential for proper treatment. Skin lesions are similar in their early stages, so manual diagnosis is difficult. Thus, artificial intelligence techniques can analyze images of skin lesions and discover hidden features not seen by the naked eye. This study developed hybrid techniques based on hybrid features to effectively analyse dermoscopic images to classify two datasets, HAM10000 and PH2, of skin lesions. The images have been optimized for all techniques, and the problem of imbalance between the two datasets has been resolved. The HAM10000 and PH2 datasets were classified by pre-trained MobileNet and ResNet101 models. For effective detection of the early stages skin lesions, hybrid techniques SVM-MobileNet, SVM-ResNet101 and SVM-MobileNet-ResNet101 were applied, which showed better performance than pre-trained CNN models due to the effectiveness of the handcrafted features that extract the features of color, texture and shape. Then, handcrafted features were combined with the features of the MobileNet and ResNet101 models to form a high accuracy feature. Finally, features of MobileNet-handcrafted and ResNet101-handcrafted were sent to ANN for classification with high accuracy. For the HAM10000 dataset, the ANN with MobileNet and handcrafted features achieved an AUC of 97.53%, accuracy of 98.4%, sensitivity of 94.46%, precision of 93.44% and specificity of 99.43%. Using the same technique, the PH2 data set achieved 100% for all metrics.