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Membrane bioreactors (MBRs) have been widely used for municipal and industrial wastewater treatment around the world due to their advantages, which include higher efficiency, smaller footprint, and lower sludge production over other conventional activated sludge (CAS) processes. However, membrane fouling that results from physicochemical interactions between the membrane and the components of the mixed liquor still remains the most challenging matter preventing the broad application of MBR technology. Recently, a considerable number of experimental and modelling investigations have been conducted concerning MBRs and membrane fouling. Despite the development of low‐fouling membrane systems, more research and engineering activities with a focus on surface modification, wastewater specifications, pre‐treatment and treatment conditions, and efficient fouling control and remedy strategies are still needed to minimize the probability of the occurrence of fouling. It is vital to investigate important aspects of the characterization and mechanisms of the fouling phenomenon to find reliable and long‐term solutions. This review provides a detailed survey of the main aspects of the MBR processes, configurations, advantages and disadvantages, fouling phenomenon, and fouling control strategies in MBRs. Past research and engineering activities in this area are critically reviewed such that pros and cons of recent developments in fouling inhibition and mitigation approaches are also discussed. The main practical and theoretical challenges for the effective utilization of MBRs in various municipal and industrial sectors are then addressed. At the end, we offer useful practical guidelines and recommendations for the better design and operation of MBRs in industrial and public communities.

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