Hypertension-induced ventricular and vascular remodeling causes myocardial infarction, heart failure, and sudden death. Most available pharmaceutical products used to treat hypertension lead to adverse effects on human health. Limited data is available on apitherapy (bee products) combinations for treatment of hypertension. This study aims to evaluate the antihypertensive effects of combinations of natural apitherapy compounds used in the medical sector to treat a variety of diseases. Rats were assigned into six groups consisting of one control group and five hypertensive groups where hypertension (blood pressure > 140/90) was induced with dexamethasone. One of these groups was used as a hypertension model, while the remaining four hypertensive groups were treated with a propolis, royal jelly, and bee venom combination (PRV) at daily oral doses of 0.5, 1.0, and 2.0 mg/kg, and with losartan 10 mg/kg. The PRV combination at all doses decreased arterial blood pressure below the suboptimal value (p < 0.001), and PRV combination treatment improved dexamethasone-induced-ECG changes. The same treatment decreased angiotensin-II, endothelin-1, and tumor growth factor β serum levels in hypertensive rats. Additionally, PRV combination improved histopathological structure, and decreased serum levels of NF-kB and oxidative stress biomarkers. We concluded that PRV combination therapy may be used as a potential treatment for a variety of cardiovascular diseases.

Introduction: Addition of nanofillers to the denture base material in order to enhance its mechanical properties may contribute to the dimensional accuracy of the processed dentures. Aim: This study was conducted to investigate the effect of zirconium oxide nanofillers addition on the dimensional accuracy of maxillary heat cured acrylic dentures. Materials and Methods: Thirty six identical maxillary waxed up dentures were constructed, divided into two equal groups(n=18), control group processed into conventional heat cured acrylic resin dentures and test group processed into 5% zirconium oxide nanofiller reinforced heat cured acrylic resin dentures. Teeth movements were estimated linearly using digital software after processing and vertically using digital caliper before and after processing. Changes in denture adaptation were measured immediately after processing and after seven days hydration in distilled water using digital software. Results: After processing, both groups showed increased Vertical dimension of occlusion with less increase with the test group. Both groups showed changes in teeth position with non-significant difference. Test group showed more tendency to inward tooth movement. Test group showed significant more denture adaptation after processing. However, denture hydration caused decrease in denture adaptation in the test group while causing enhancement in denture adaptation with the control group. Conclusion: Zirconium oxide nanofillers reinforcement showed nearly comparable results of dimensional accuracy to the conventional dentures with negative results on hydration.