OBJECTIVE:In this study, we aimed to compare the cardiovascular risk factors that might be associated with inflammation, atherosclerosis and metabolic syndrome between hemodialysis and peritoneal dialysis patients.METHODS:Fifty hemodialysis and 50 peritoneal dialysis patients who had been receiving dialysis therapy for at least one year were included in the study. Venous blood samples were taken after 12 hours of fasting, and serum glucose, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, C-reactive protein, fibrinogen and homocysteine levels were measured. The presence of atherosclerotic plaques in the carotid artery was evaluated by carotid Doppler ultrasound. These data were analyzed by Student's t test, the chi-square test and the Mann-Whitney U test, as appropriate.RESULTS:No difference was found between the hemodialysis (n=50) and peritoneal dialysis (n=50) patient groups regarding mean age, gender distribution, body mass index or dialysis duration (p=0.269, 0.683, 0.426, and 0.052, respectively). LDL-cholesterol, fibrinogen and homocysteine levels were significantly higher in peritoneal dialysis patients (p=0.006, 0.001, and 0.002, respectively). In patients with diabetes mellitus (n=17) who were undergoing renal replacement therapy, LDL-cholesterol and fibrinogen levels were significantly higher than in patients without diabetes mellitus who were undergoing renal replacement therapy (p=0.001 and 0.004, respectively).CONCLUSION:In our study, cardiovascular risk factors (especially LDL-cholesterol) were more frequent in peritoneal dialysis patients than in hemodialysis patients.

Biopsies in the elderly are as safe as in the general population. Renal biopsy should be performed to provide an accurate diagnosis and initiate specific treatment in elderly patients.

Objective:The effects of acute hemodialysis session on pulse wave velocity are conflicting. The aim of the current study was to assess the acute effects of ultrafiltration on the aortic mechanical properties using carotid-femoral (aortic) pulse wave velocity and pulse propagation time.Methods:A total of 26 (12 women, 14 men) consecutive patients on maintenance hemodialysis (mean dialysis duration: 40.7±25.6 (4-70) months) and 29 healthy subjects (13 women, 16 men) were included in this study. Baseline blood pressure, carotid-femoral (aortic) pulse wave velocity, and pulse propagation time were measured using a Complior Colson device (Createch Industrie, France) before and immediately after the end of the dialysis session.Results:While systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, and pulse wave velocity were significantly higher in patients on hemodialysis than in healthy subjects, pulse propagation time was significantly higher in healthy subjects. Although body weight, systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, and pulse wave velocity were significantly decreased, heart rate and pulse propagation time were significantly increased after ultrafiltration. There was a significant positive correlation between pulse wave velocity and age, body height, waist circumference, systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, and heart rate.Conclusion:Although hemodialysis treatment may chronically worsen aortic mechanical properties, ultrafiltration during hemodialysis may significantly improve aortic pulse wave velocity, which is inversely related to aortic distensibility and pulse propagation time.

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Son dönem böbrek hastalığı (SDBH) nedeni ile kronik hemodiyaliz (HD) tedavisi görmekte olan hasta popülasyonu, tüm dünyada olduğu gibi Türkiye'de de artmaktadır. Bu hastalara ait bilgilerin kaydedildiği veri tabanlarında yapılacak analizler, mevcut durum hakkında tespitler yapılmasını ve HD tedavisinde gelişme alanlarının belirlenmesini sağlayarak hastaların tedaviden daha fazla yarar görmelerine katkıda bulunabilir. Bu çalışmada, Türkiye'de kronik HD tedavisi görmekte olan hastaların demografik ve klinik özelliklerinin incelenmesi amaçlandı. Gereç ve Yöntemler: Bu tanımlayıcı çalışma için, Ocak 2017-Şubat 2018 tarihleri arasındaki bir yıllık zaman diliminde Türkiye'nin 7 bölgesindeki 93 merkezde SDBH nedeni ile kronik HD tedavisi görmekte olan hastalar elektronik ortamda kaydedildi. Hastaların bazı demografik özellikleri ile birlikte klinik özellikleri incelendi. Bulgular: Çalışmaya, kronik HD tedavisi görmekte olan 2.461 hasta dâhil edildi. Ortalama yaşı 56,7±14,3 yıl olan çalışma popülasyonunun %65,5'ini erkekler oluşturuyordu. Ortalama SDBH süresi 5,4±6,1 yıl idi. Çalışma popülasyonunun %92,8'i haftada üç kez HD tedavisi alıyordu. Hastaların %74,8'inde eşlik eden en az bir hastalık ve %9,1'inde hastaneye yatış öyküsü saptandı. Bu hastane yatışlarının %21,7'sinde kardiyak etiyoloji mevcuttu. Çalışma popülasyonunun %79,6'sında anemi bulundu. Eritropoez uyarıcı ajan alan hastalar, tüm popülasyonun %57,4'ünü oluşturuyordu. Hastaların %80,0'ında fosfat bağlayıcı ajan kullanımı tespit edildi. Statin kullanan hastaların oranı %8,9 idi. Sonuç: Çok-merkezli bu kayıt çalışması ile Türkiye'de kronik HD tedavisi görmekte olan hastaların klinik özellikleri geniş ölçekte ortaya kondu. Görece genç yaşlarda olan çalışma popülasyonunda azımsanamayacak sıklıkta saptanan komorbidite ve kardiyak hastane yatışı öyküsü, kısa ve uzun dönem izlemlerdeki klinik özellik değişim trendiyle birlikte öngördürücü ve prognostik faktörlerin ortaya çıkarılmasına ışık tutabilir. Anah tar Ke li me ler: Böbrek diyalizi; kronik böbrek yetmezliği; kayıt çalışması; anemi; kardiyovasküler hastalıklar ABS TRACT Objective: The number of patients who received chronic hemodialysis (HD) due to end-stage renal disease (ESRD) has increased both at global and national level. Analyses of disease registries in these patients could contribute to improved therapeutic benefits by addressing potential areas of development in HD therapy after determining current situation. This study aimed to investigate demographic and clinical characteristics of chronic HD patients in Turkey. Material and Methods: This descriptive study enrolled patients who were under chronic HD therapy due to ESRD in 93 centers of seven regions of Turkey between January, 2017 and February, 2018. Some demographic and clinical characteristics of the patients were examined. Results: A total of 2.461 chronic HD patients were included to the study. The mean age of the patients was 56.7±14.3 and men constituted 65.5% of the study population. The mean duration of ESRD was 5.4±6.1 years. Most of the p...