Objectives: To explore the influence of epilepsy on quality of life )QoL( among people with epilepsy in Saudi Arabia, and its association with sociodemographic and clinical characteristic aspects in the Qassim region. Methods:A cross-sectional multi-centered study done in the Qassim region from June 2018 to May 2019. A self-administered questionnaire was provided to 216 participants who attended the neurology clinic. We used a validated Arabic version of the QoL in Epilepsy )QOLIE-31( to measure the QoL. Original ArticlesResults: The mean of the overall QOLIE-31 score was 64.23 ± 17.8. we found that employment status had a significant influence on the overall score )p<0.001( and all other QOL domains )rho ranged from -.136 for energy fatigue to -.193 for social function( Patients with focal seizures were significantly higher in emotional wellbeing )rho=-.159(, seizure worry )rho=-.226(, cognitive function )rho=-.166( and overall score )p=0.010( than patients with the generalized type. Monotherapy patients have higher scores in total )p<0.001( and all subscales except seizure worry and emotional wellbeing than those on polytherapy. Conclusion:Employment status, type of seizure, and AED number are the most important factors affecting Saudi patient's QoL.