We investigate the transverse momentum resummation for top quark pair production at hadron colliders using the soft-collinear effective theory and the heavy-quark effective theory. We derive the factorization formula for tt production at small pair transverse momentum, and show in detail the procedure for calculating the key ingredient of the factorization formula: the next-to-leading order soft functions. We compare our numerical results with experimental data and find that they are consistent within theoretical and experimental uncertainties. To verify the correctness of our resummation formula, we expand it to the next-to-leading order and the next-to-next-to-leading order, and compare those expressions with the exact fixed-order results numerically. Finally, using the results of transverse momentum resummation, we discuss the transverse-momentum-dependent forward-backward asymmetry at the Tevatron.

The human cathelicidin LL-37, a pleiotropic host defense peptide, is down-regulated in gastric adenocarcinomas. We therefore investigated whether this peptide suppresses gastric cancer growth. LL-37 lowered gastric cancer cell proliferation and delayed G(1)-S transition in vitro and inhibits the growth of gastric cancer xenograft in vivo. In this connection, LL-37 increased the tumor-suppressing bone morphogenetic protein (BMP) signaling, manifested as an increase in BMP4 expression and the subsequent Smad1/5 phosphorylation and the induction of p21(Waf1/Cip1). The anti-mitogenic effect, Smad1/5 phosphorylation, and p21(Waf1/Cip1) up-regulation induced by LL-37 were reversed by the knockdown of BMP receptor II. The activation of BMP signaling was paralleled by the inhibition of chymotrypsin-like and caspase-like activity of proteasome. In this regard, proteasome inhibitor MG-132 mimicked the effect of LL-37 by up-regulating BMP4 expression and Smad1/5 phosphorylation. Further analysis of clinical samples revealed that LL-37 and p21(Waf1/Cip1) mRNA expressions were both down-regulated in gastric cancer tissues and their expressions were positively correlated. Collectively, we describe for the first time that LL-37 inhibits gastric cancer cell proliferation through activation of BMP signaling via a proteasome-dependent mechanism. This unique biological activity may open up novel therapeutic avenue for the treatment of gastric cancer.

We develop a framework for a systematic resummation of the transverse momentum distribution of top-quark pairs produced at hadron colliders based on effective field theory. Compared to Drell-Yan and Higgs production, a novel soft function matrix is required to account for the soft gluon emissions from the final states. We calculate this soft function at the next-to-leading order, and perform the resummation at the next-to-next-to-leading logarithmic accuracy. We compare our results with parton shower programs and with the experimental data at the Tevatron and the LHC. We also discuss the implications for the top quark charge asymmetry.

Abstract:We investigate the resummation effects in the Standard Model Higgs boson pair production through gluon-gluon fusion at the LHC with soft-collinear effective theory. We calculate the total cross section and the invariant mass distribution at Next-to-Nextto-Leading-Logarithmic level with π 2 -enhanced terms resummed, which are matched to the QCD Next-to-Leading Order results. In the high order QCD predictions exact top quark mass effects are included in full form factors. Our results show that the resummation effects increase the Next-to-Leading Order results by about 20% ∼ 30%, and the scale uncertainty is reduced to 8%, which lead to increased confidence on the theoretical predictions. The PDF+α s uncertainties are almost not changed after including resummation effects. We also study the sensitivities of the total cross section and the invariant mass distribution to the Higgs boson self-coupling. We find that the total cross section and the invariant mass distribution shape depend strongly on the Higgs boson self-coupling, and therefore it is possible to extract Higgs boson self-coupling from the total cross section and invariant mass distribution when the measurement precision increases at the LHC.

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