Summary. An acid-titration method for the determination of bicarljonate and titratable acid in the one sample of urine is described. The method needs only one manipulation of the sample of urine, and was devised to simplify routine laboratory methodology. The accuracy and precision of the urinary bicarbonate method during routine laboratory use is comparable to that obtained by using the Van Slyke manometric apparatus.The titratable acid obtained by this method gave values which were persistently lower by about 0-5 niM/L than those obtained by the direct titration method at present in use. This difference was attributed to the carbonic acid present in urine which is partly titrated in the determination of titratable acid by the direct method.

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Low-dose aspirin does not appear to have a significant effect on perinatal morbidity. The increase in weight at birth associated with low-dose aspirin therapy is due to prolongation of pregnancy rather than prevention of intra-uterine growth retardation.