Production of matrix-degrading enzymes by the synovium may induce progressive pathologic rupture of the CCL. Therefore, these collagenolytic pathways may offer a novel target for medical therapy of joint inflammation in canine patients with cruciate disease.
Ruptured CCLs contained a high number of nonviable cells but not a great number of apoptotic cells. Repair processes in the epiligamentous region of the CCL include a metabolic response to hypoxia, suggesting that necrosis of ligament fibroblasts and transformation of surviving cells to a spheroid phenotype may be a response to hypoxia cause by microinjury or inadequate blood flow.
Regional odontodysplasia is a rare human dental anomaly. This non-hereditary developmental condition affects dental tissues derived from both the mesoderm and ectoderm. Diagnosis is based mainly on clinical and radiographic findings, although it is often supported with histopathology. This case report describes an extraction in a juvenile dog with a partially erupted, malformed canine tooth having clinical, radiographic, and histologic features consistent with regional odontodysplasia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.