A mild, efficient, and novel rhodium catalyzed asymmetric cyclization-addition domino reaction of oxa/azabenzonorbornadienes and 1,6-enynes is documented. Through the use of a [Rh(COD)]BF-(R)-An-SDP catalytic system, highly enantioenriched cyclization-addition products were obtained in good yields and with excellent enantioselectivities.
The
asymmetric transfer hydrogenation of heterobicyclic alkenes
was accomplished by using water as the sole hydrogen source. The transformation
was co-catalyzed by Pd(OAc)2/Zn(OTf)2 dual catalyst
with metallic zinc as reducing agent. Various azabenzonorbornadienes
and oxabenzonorbornadienes were transformed to the corresponding chiral
1,2-dihydronaphthalenes by the asymmetric reductive ring-opening reactions
with good to excellent enantioselectivities.
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