We thank Drs Yoneyama and Akashi for their important reference to the confounding influence of respiration on biventricular volume assessment by real-time cardiac magnetic resonance imaging. As we noted in the Discussion, changes in biventricular volumes "may be caused by physiological differences in preload attributable to the fall in intrathoracic pressures during inspiration and cardiac translation through the imaging plane."1 Real-time cardiac magnetic resonance imaging provides a novel means of expanding on the eloquent work of Natarajan et al 2 on assessing the influence of the respiratory pump on cardiac filling and function. This interaction between breathing and cardiac function has received limited attention, but now we have an excellent noninvasive tool for very accurately detailing changes in both right and left ventricular volumes with various respiratory maneuvers. We hope to provide novel data in the peer-reviewed literature soon that will detail the importance of this respiratory pump in enhancing cardiac filling. We slightly disagree with the assertion that breath-hold imaging should be considered a gold standard. Breath-holding is a nonphysiological surrogate that has previously been necessary to enable gating of cardiac magnetic resonance images. Real-time imaging enables the investigator to apply the accuracy of cardiac magnetic resonance to real physiological settings. We can neither ignore the fact that our patients breathe nor ignore the fact that most of our patients develop symptoms with exertion. This new methodology finally enables us to accurately measure cardiac function when it really matters. DisclosuresNone. References
Echocardiographic estimates of RV and pulmonary vascular function are feasible during exercise and identify pathology with reasonable accuracy. They represent valid screening tools for the identification of pulmonary vascular disease in routine clinical practice.
BackgroundPatients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, and the effect of sildenafil during exercise in these patients.Methods and ResultsFourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (≤25 mm Hg) post‐PEA underwent cardiopulmonary exercise testing, followed by cardiac magnetic resonance imaging with simultaneous invasive mPAP measurement during incremental supine cycling exercise. Peak oxygen consumption and peak heart rate were significantly reduced in post‐PEA and CTEPH patients compared to controls. The mPAP–cardiac output slope was steeper in post‐PEA patients than in controls and similar to CTEPH. Relative to controls, resting right ventricular ejection fraction was reduced in CTEPH, but not in post‐PEA patients. In contrast, peak exercise right ventricular ejection fraction was reduced both in post‐PEA and CTEPH patients. Exercise led to reduction of pulmonary arterial compliance in all groups. Nevertheless, resting pulmonary arterial compliance values in CTEPH and post‐PEA patients were even lower than those in controls at peak exercise. In post‐PEA patients, sildenafil did not affect resting hemodynamics nor right ventricular function, but decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction.ConclusionsExercise intolerance in post‐PEA patients is explained by abnormal pulmonary vascular reserve and chronotropic incompetence. The mPAP/cardiac output slope and pulmonary arterial compliance are sensitive measures demonstrating abnormal resistive and pulsatile pulmonary vascular function in post‐PEA patients. These abnormalities are partially attenuated with sildenafil.
Among athletes with normal cardiac function at rest, exercise testing reveals RV contractile dysfunction among athletes with RV arrhythmias. RV stress testing shows promise as a non-invasive means of risk-stratifying athletes.
Background-Accurate measures are critical when attempting to distinguish normal from pathological changes in cardiac function during exercise, yet imaging modalities have seldom been assessed against invasive exercise standards. We sought to validate a novel method of biventricular volume quantification by cardiac MRI (CMR) during maximal exercise. Methods and Results-CMR was performed on 34 subjects during exercise and free-breathing with the use of an ungated real-time (RT-ungated) CMR sequence. ECG and respiratory movements were retrospectively synchronized, enabling compensation for cardiac cycle and respiratory phase. Feasibility of RT-ungated imaging was compared with standard exercise CMR imaging with ECG gating (gated); accuracy of RT-ungated CMR was assessed against an invasive standard (direct Fick); and reproducibility was determined after a second bout of maximal exercise. Ventricular volumes were analyzed more frequently during high-intensity exercise with RT-ungated compared with gated CMR (100% versus 47%; P<0.0001) and with better interobserver variability for RT-ungated (coefficient of variation=1.9% and 2.0% for left and right ventricular stroke volumes, respectively) than gated (coefficient of variation=15.2% and 13.6%; P<0.01). Cardiac output determined by RT-ungated CMR proved accurate against the direct Fick method with excellent agreement (intraclass correlation coefficient, R=0.96), which was highly reproducible during a second bout of maximal exercise (R=0.98). Conclusions-When RT-ungated CMR is combined with post hoc analysis incorporating compensation for respiratory motion, highly reproducible and accurate biventricular volumes can be measured during maximal exercise. (Circ Cardiovasc Imaging. 2013;6:329-338.)
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