Objective: Chinese pediatricians are working on the front line to fight COVID-19. They have published a great amount of first-hand clinical data. Collecting their data and forming a large sample for analysis is more conducive to the recognition, prevention and treatment of coronavirus disease 2019 in children. The epidemic prevention and control experience of Chinese pediatricians should be shared with the world. Methods: By searching Chinese and English literature, the data of 406 children with COVID-19 in China were analyzed. Results: It was found that the clustered incidence of children's families is a dynamic transmission feature; the incidence is low; asymptomatic infections and mild cases account for 44.8%, with only 7 cases of critical illness; laboratory examination of lymphocyte counts is not reduced, as it is for adults; chest CT findings are less severe than those for adults. These presentations are the clinical features of COVID-19 in children. Only 55 of the 406 cases were tested by anal swab for virus nucleic acid, 45 of which were positive, accounting for 81.8% of stool samples. Conclusion: There are more children than adults with asymptomatic infections, milder conditions, faster recovery, and a better prognosis. Some concealed morbidity characteristics also bring difficulties to the early identification, prevention and control of COVID-19. COVID-19 screening is needed in the pediatric fever clinic, and respiratory and digestive tract nucleic acid tests should be performed. Efforts should be made to prevent children from becoming a hidden source of transmission in kindergartens, schools or families. Furthermore, China's experience in treating COVID-19 in children has led to faster recovery of sick children.
Nearly mature newborn rabbits (gestational age 29.5 days) were tracheotomized at birth and received, via the tracheal cannula, 6 ml/kg body weight of a filtered saline suspension of human meconium, 65 or 130 mg/ml. Animals were kept in body plethysmographs and ventilated for 60 min with standardized tidal volume (8-10 ml/kg). Aspiration of meconium caused, in both groups, a statistically significant reduction in lung-thorax compliance, elevated PCO2 in heart blood and reduced alveolar volume density (Vv) in histological sections. Both groups responded to treatment with exogenous surfactant (Curosurf, 200 mg/kg) with a moderate, statistically significant improvement in lung-thorax compliance, PCO2 and alveolar Vv. Our data indicate that respiratory failure after neonatal meconium aspiration may be influenced favorably by treatment with exogenous surfactant.
We present TLR, a traffic-light-based intelligent routing strategy for NGEO satellite IP networks. In TLR, a set of traffic lights are used to indicate the congestion status at both the current node and the next node. When a packet travels along a pre-calculated route to the destination, it may adjust the route dynamically, according to the real-time color of traffic lights at each intermediate node. Through the combination of preliminary planning and real-time adjustment, each packet can eventually get an approximately optimal transmission path. The multi-path routing mechanism in TLR can help achieve a good distribution of traffics when the network traffic increases. The Public Waiting Queue scheme in TLR can fully utilize free spaces of the buffer queues and lower the packet drop rate.While the concept of TLR has many advantages, it may result in endless-loop of routing. To eliminate this phenomenon, a defense scheme is incorporated in the design of TLR. A set of simulations are conducted using the Network Simulator (version 2) to verify the good performance of TLR, in terms of lower packet drop rate, better distribution of traffics and higher throughput, over the entire satellite constellation.Index Terms-NGEO satellite network, traffic light, intelligent routing, packet drop rate, load balance.
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