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In the present study the near-wall behaviour of turbulent channel flow at ! = 1000, 2000 is investigated in the minimal domain designed to maintain healthy turbulence up to ! ≈ 100. The minimal flow units can reproduce statistical behaviour of small-scale motions in the full-sized channel in the absence of outer motions, which implies that the minimal flow unit could embody the universal properties of near-wall turbulence.Furthermore, combined with the signals of outer large-scale motions, the signals extracted from the minimal channels are used to predict the near-wall turbulence fluctuations in the full-sized channel and build the off-wall boundary conditions for the largeeddy simulation in the outer region.