L». DOS SANTOS-WERNECK, TAMARA CHECCACCI-BALOD, GRAÇA TXJMA RESUMO -Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada). O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnostica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia grave constituem associação pouco frequente. A presença de esclerodermia e miastenia grave é rara. Não encontramos na literatura a coincidência destas três doenças.PALAVRAS-CHAVE: miastenia grave, tireoidite, esclerodermia.Scleroderma, thyroiditis and myasthenia gravis: case report.SUMMARY -A thirty-six years old woman with myasthenia gravis developed cold intolerance after two years, and Hashimoto's thryroiditis diagnosis was established. Four years later she exhibited skin thickening (limited scleroderma). Laboratory and clinical findings suggested the CREST type of systemic sclerosis. Difficulty in scleroderma diagnosis is discussed, as overlap of syndromes. Hashimoto's thyroiditis and myasthenia gravis are infrequently associated. Occurrence of scleroderma and myasthenia gravis in the same patient is rare. The coincidence of these three disorders was not found in literature.K E Y WORDS: myasthenia gravis, thyroiditis, * scleroderma. Doença auto-imun e é reconhecid a quando existe m reaçõe s entr e auto-anticorpos e auto-antígenos , determinand o manifestaçõe s clínicas . Schoenfel d e Schwartz 18 refere m semelhanças imunogenéticas, comuns às doença s auto-imunes, como fato r primordial , poi s exist e ocorrênci a d a simultaneidade . Escleros e sistê-mica progressiv a (ESP), tireoidit e de Hashimot o (TH) e miasteni a grav e (MG) ca
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