Nanocomposites (NCPs) with excellent physical, chemical and optical properties have been broadly used for commercial products and industrial applications. Based on these features of the NCPs, we prepared colloidal gold (Au) and organic cinnamon (Cin) NCPs by laser irradiated Au and Cin targets separately immersed in glass container fulfilled with different pH solutions (5.0 to 8.0). A Q-switched pulse laser ablation in liquid (PLAL) technique was employed to customize morphology, structural and optical characteristics of these grown nanoparticles inside various pH solutions at room temperature. Colloidal solution of gold-cinnamon nanocomposites (Au-Cin NCPs) was characterized via Transmission electron microscopy (TEM), Ultraviolet-visible (UV-Vis) spectrometer and CIE 1931 chromaticity diagram. TEM image and SAED patters revealed spherical shaped Au-Cin NCPs with a particle diameters of 5.19 ± 1.23 nm and a nanocrystalline face centred cubic (FCC) nucleation. These plasmonic Au-Cin NCPs very strong UV-Vis absorbance bands at (270 nm and 522 nm) and CIE color coordinate (color temperature of 6437.001 K and color purity of 11.9130 %). It is established that the PLAL made-up Au-embedded Cin NCPs may be useful for the formulation of nanobiomedicine drugs.
Objective: In this study, silver nanoparticles (SNPs) were synthesized using an aqueous extract of Trainthema portulacastrum and silver ions (Ag+) which have been proven against certain pathogenic bacterial strains and hepatocellular carcinoma (HepG2) cell line.
Methods:The bio fabricated nanoparticles were confirmed by surface plasmon resonance which were characterized by biophysical measures utilizing the ultraviolet-visible spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray, and transmission electron microscope (TEM), Fourier transform infrared spectroscopy, particle size analyzer, and X-ray diffraction. Antibacterial efficacy against Enterobacter aerogens, Proteus mirabilis, Escherichia coli, Staphylococcus epidermis, and Bacillus subtilis. The effect of SNPs tested against HepG2 and NIH/3T3 cell line exhibits a dose-dependent toxicity.
Results and Conclusion:The SEM and TEM images confirmed the presence of spherical and hexagonal shape (0.3-4 µm) of nanocrystalline particles with the size range of 11.5-29.2 nm. The average particles size of SNPs is 190.3±17.0 nm. Antibacterial activity was carried out by agar well diffusion method against different pathogenic bacteria of which B. subtilis showed a significant zone of inhibition 8.66 mm and 12.0 mm for aqueous plant extract and synthesized SNPs. The effect of SNPs tested against HepG2 and NIH/3T3 cell line exhibits a dose-dependent toxicity. In case of HepG2, the cell viability was decreased to 50% (IC 50 ) at the concentration of 173.8±0.84 µg/mL. From the results, it can be concluded that the SNPs fabricated using green synthesis method will be a promising candidate in the biomedical field, due to its high bioactive properties.
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