A series of diverse and complex hybrid structures of indole bearing fluorene were obtained in the presence of DDQ and FeCl3 with high regioselectivity under mild conditions from biaryl tethered 3-(methylene)indoline in good to excellent yields.
We developed a novel Pd-catalysed enantioselective synthesis of C-N bond in the chiral scaffold of DNA. The non-covalently linked Pd(phen)(OAc)2 to st-DNA catalysed the Markonicov hydroamination of methoxyamine into β-nitrostyrene...
In the present study, we herein report a DDQ-catalyzed
new protocol
for the synthesis of substituted 3-acylindoles. Being a potential
system for virtual hydrogen storage, introduction of catalytic DDQ
in combination with Fe(NO3)3·9H2O and molecular oxygen as co-catalysts offers a regioselective oxo-functionalization
of C-3 alkyl-/aryllidine indolines even with scale-up investigations.
Intermediate isolation, their spectroscopic characterization, and
the density functional theory calculations indicate that the method
involves dehydrogenative allylic hydroxylation and 1,3-functional
group isomerization/aromatization followed by terminal oxidation to
afford 3-acylindoles quantitatively with very high regioselectivity.
This method is very general for a large number of substrates with
varieties of functional groups tolerance emerging high-yield outcome.
Moreover, molecular docking studies were performed for some selected
ligands with an RNA-dependent RNA polymerase complex (RdRp complex)
of SARS-CoV-2 to illustrate the binding potential of those ligands.
The docking results revealed that few of the ligands possess the potential
to inhibit the RdRp of SARS-Cov-2 with binding energies (−6.7
to −8.19 kcal/mol), which are comparably higher with respect
to the reported binding energies of the conventional re-purposed drugs
such as Remdesivir, Ribavirin, and so forth (−4 to −7
kcal/mol).
A new synthetic protocol was developed for the selective synthesis of diverse 3‐substituted indoles through tandem carbon–carbon bond formation and isomerization of 3‐benzylidene‐1‐tosylindoline by direct use of alcohols as alkylating agents in the presence of catalytic FeCl3. This method is applicable to a wide range of substrates containing varieties of functional groups. Direct use of alcohols, such as benzylic, allylic, and propargylic alcohols, as electrophiles and the use of non‐toxic iron catalyst makes this strategy attractive and environmentally benign. A plausible mechanism has also been proposed for this tandem reaction.
An efficient one-pot synthesis of indole-xanthydrol hybrid is described in the presence of catalytic combinations of Fe(NO3)3/FeCl3. This strategy involves through a series of reactions such as allylic oxidation, isomerisation,...
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