Erythema discromicum perstans is clinically characterized by asymptomatic, hyperpigmented macules of various size on the face, trunk and extremities. It typically occurs in the second decade of life and generally affects those with phototype IV skin. The etiology of erythema discromicum perstans is unknown but associations with endocrinopathies, infestations, infections, and drug allergies have been reported. The association with oral contraceptives and progesterone injections has not been reported yet in the literature. Herein, we report a case of a 34 year old woman who presented with extensive and progressive erythema discromicum perstans induced and/or exacerbated by the ingestion of oral contraceptives and multiple progesterone injections. We aim to emphasize the "probable" side effect of these drugs. Awareness of this probable association deserves attention due to the widespread use of oral contraceptive pills and/or progesterone injections.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.