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We present a methodology and a planning and design support software tool for evaluating walkability and pedestrian accessibility of places which are relevant for people’s capabilities, and thus an important component of quality of life in cities. A multicriteria evaluation model, at the core of the decision support system, is used to assign walkability scores to points in urban space. Walkability scores are obtained through algorithms which process spatial data and run the evaluation model in order to derive potential pedestrian routes along the street network, taking into account the quality of urban space on several attributes relevant for walkability. One of its notable characteristics is a certain reversal of perspective in evaluating walkability: the walkability score of a place does not reflect how that place is per se walkable, but instead how and where to can one walk from there, that is to say, what is the walkability the place is endowed with. This evaluation incorporates three intertwined elements: the number of destinations/opportunities reachable by foot, their walking distances, and the quality of the paths to these destinations. In this article, we furthermore demonstrate possible uses of the support system by reporting and discussing the results of a case-study assessment of a project for the Lisbon’s Segunda Circular (Second Ring Road). The software tool is made freely available for download

The aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (Citrus bergamia), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative profile was carried out by LC-ESI/MS using three different approaches: targeted (searching analytes already reported in bergamot extract), semi-targeted (a selective search of 3-hydroxy-3-methylglutarate [HMG] derivatives involved in the cholesterol reducing activity of BPF) and untargeted. A total number of 108 compounds were identified by using the three approaches, 100 of which are present in both the extracts thus demonstrating a good qualitative overlapping of polyphenols between the two extracts. The antioxidant activity was higher for BLPF in respect to BFPF but when normalized in respect to the polyphenol content they were almost overlapping. Both the extracts were found to dose dependently inhibit cell inflammation stimulated with IL-1α. In conclusion, the comparison of the qualitative and quantitative profile of polyphenols as well as of the antioxidant and anti-inflammatory activity of bergamot leaf and fruit well indicates that leaf is a valid source of bergamot polyphenol extraction and an even richer source of polyphenol in respect to the fruit.