A key goal in the control of canine visceral leishmaniosis (CVL) has been the development of vaccines with a highly protective capability to interrupt the parasite transmission cycle. However, in addition to promising vaccine searches, researchers have sought to develop new drugs capable of eliminating parasites in humans and dogs. With that in mind, this study analyzed an immunotherapeutic approach in dogs naturally infected with Leishmania infantum. Fourteen dogs were divided into two groups and received a protocol of immunotherapeutic treatment with five doses of total antigens of Leishmania amazonensis or total antigens of L. amazonensis plus saponin (LaSap). All the animals were evaluated before and 90 and 180 days after treatment, hematology, liver and renal biochemical analyzes, serology, lymphoproliferation, and parasite load by qPCR. The results of immunotherapy with the LaSap vaccine were promising since it was able to preserve hematological and biochemical parameters, as well as improve the clinical status, reduce serum levels of IgG, induce a lymphoproliferative capacity against soluble antigens of L. infantum, and provide a marked reduction in the parasite load after LaSap immunotherapeutic treatment. The immunotherapy data demonstrated that LaSap offered the best formulation to induce clinical cure associated with a parasite load reduction in the skin. However, after 180 days of treatment, the animals again showed a slight increase in parasitism, indicating that immunotherapy does not promote sterilizing cure and a new immunotherapeutic intervention would be necessary to maintain low parasitism in dogs.
ResumoAo ler uma revista para o público feminino, o que mais vemos são mulheres magras, de biquíni, olhos claros e altas. Nelas, é estampado o rótulo de mulher bonita, independente e experiente. Mas afinal, qual é o conceito de beleza estabelecido? Quem ditou esse padrão? Com essa análise, mostramos que as revistas tendem a criar mulheres que não existem, fortalecendo o machismo e expondo a mulher de maneira prejudicial. Palavras-chave: Jornalismo, revista, revistas segmentadas, feminismo. AbstractWhen we read women's magazines, we see tall, bright-eyed skinny women, wearing bikini. This image is associated with beauty, independence and experience. Despite that, what is the real beauty pattern? Who has created this pattern? With this work, we show that these magazines try to invent a kind of women that doesn't really exist. And they strengthen a macho culture and expose women in a damaging way. Keywords: Journalism, magazine, segmented maganizes, feminism. IntroduçãoAs mulheres buscam melhorar fisicamente, profissionalmente e/ou emocionalmente.Nunca se veem satisfeitas. Por que tanta insatisfação? A mídia, as novas tecnologias e a sociedade em geral criam uma mulher que não existe. A mulher modelo, que todas deveriam seguir, é aquela extremamente preocupada com a beleza física, que faz diversos recortes e colagens no corpo, que tem que trabalhar e cuidar bem do marido em casa para ele não procurar outra melhor na rua, que se preocupa antes em satisfazer sexualmente o parceiro para depois preocupar-se consigo mesma, que precisa ter filhos para se realizar, que deve ser jovem para
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.