Background: Warts are benign tumors of the skin and mucosa and are caused by human papilloma virus (HPV). They are one of the most common skin diseases found mainly in children and adolescents. Although most of the warts disappear spontaneously or respond to the usual therapeutic measures, resistant forms of the warts impose a problem in dermatology. Intralesional injection of bleomycin has been tried in the treatment of resistant warts with variable results in different studies.Objectives: This study aimed to assess the efficacy of intralesional injection of bleomycin in resistant warts. Patients and Methods: In this cross-sectional study, a total of 130 warts in 30 patients were treated with 1 mg/mL intralesional injection of bleomycin. Patients received one to three doses of bleomycin every four weeks, and were followed for six months. Response to the treatment was categorized as complete resolution, partial resolution, and nonresponsive. We employed SPSS version 13 to perform t test and analysis of variance (Anova) as statistical methods for analyzing the data. Results: Out of 130 warts, 126 (97%) cases showed resolution after bleomycin injections. Ninety-five warts (73%) showed complete resolution and 31 (24%) cases showed incomplete resolution. The cure rate (80%) was better in warts with the size smaller than 20 mm in diameter in comparison with larger lesions (46%). After six months follow-up, 7 patients showed recurrence. Recurrence was seen more among those with greater number of warts. Conclusions: This form of treatment for resistant warts would be reliable, safe, and acceptable to the patients if it is performed under care and with proper dose and concentration.
Background: Various skin diseases such as psoriasis, lichen planus, and alopecia areata can be associated with structural nail lesions. However, nail lesions prevalence in patients with severe acne vulgaris is not determined. This study aimed to determine the frequency and types of nail lesions in patients with severe acne vulgaris. Methods: In this cross-sectional study, 235 patients with severe acne vulgaris were included from the clinic of dermatology of Rasoul-e-akram Hospital during the 2010-2011. The patients had no history of treatment for acne vulgaris. Patients initially underwent clinical examination, and severity of acne was determined among them. Demographic characteristics such as sex, age, and blood type, and nail disorders including brittleness, onycholysis, and leukonychia were investigated in these patients. Data were analyzed using SPSS 18 software. Results: In this study,79 (33.6%) patients with severe acne vulgaris had nail involvement and the frequency of nail lesions in this study were as follow: brittle nails 26.8% (63 cases); leukonychia 18.2% (43 cases); parrot-beaked nails 3.4% (8 cases) and onycholysis 1.3% (3 cases). Nail disorders in patients with severe acne vulgaris were not associated with sex, blood group, and the severity and distribution of acne lesions. However, the lower age of the patients was associated with the incidence of nail disorders.
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