Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology that affects several organs. The fatal type of Langerhans cell histiocytosis is called Letterer Siwe disease (LSD) which is multisystem with a poor prognosis. Herein, we report a 20-month-old male who was admitted for recurrent pulmonary infections at the age of 10 months. Diagnostic workup revealed a Letterer-Siwe disease. The patient was treated with a good response.
Allergic diseases in children have increased significantly. In recent years, it affects up to 35% of children. The current study aimed to investigate the value of the umbilical cord blood total IgE levels in the prediction of the development of allergic diseases during 8 years of follow-up. Methods — In cross-sectional study included 500 infants who were born in the obstetrics department at Tishreen and Al-Assad University Hospitals during the period 2007-2015. Questionnaires were administered after the birth included gender, gestational age, birth weight, mode and season of delivery, smoking during pregnancy, and family history of allergic diseases. Umbilical cord blood total IgE levels were measured. The infants were followed up for eight years for subsequent development of allergic disorders. Results — 214 (42.8%) of 500 newborns had high umbilical cord blood total IgE levels. We followed 143 of 214 newborns for 8 years; there was an allergic family history in 51.7% of newborns. During the following period, allergic diseases developed in 76.22% of the children with high umbilical cord blood total IgE levels. Allergic symptoms in children varied between nasal allergy (19.6%), skin allergy (eczema and urticarial) (25.2%), childhood asthma (31.5%). The rate of allergic symptoms development in the presence of two factors (family history and high umbilical cord blood total IgE) was 51.7%. Conclusion — We found a high prevalence of allergic diseases in children with high umbilical cord blood total IgE. The current study could be used as a preventative strategy to reduce the risk of allergic diseases by predictive of subsequent.
Allergic diseases in children have increased significantly in recent years and now affect up to 35% of children. This study aimed to investigate the total IgE level in newborn’s umbilical cord blood and its association with the development of allergic diseases during 8 years. Methods: In cross-sectional study included 500 infants who were born in the obstetrics department at Tishreen and Al-Assad University Hospitals during the period 2007-2015. Questionnaires were administered after the birth of the infant included gender, gestational age, birth weight, mode and season of delivery, smoking during pregnancy, family history of the allergic diseases, and umbilical cord blood was obtained for measurement of total immunoglobulin E (IgE) levels. We followed the newborns for eight years through clinical examination to investigate the development of allergic diseases. Results: Of 500 newborns, 214 (42.8%) were classified as having high total immunoglobulin E in umbilical cord blood. We followed 143 of 214 newborns for 8 years. There was an allergic family history in 51.7% of newborns. During the following period, the allergic diseases developed in 76.22% of the children with high total immunoglobulin E in umbilical cord blood. Allergic symptoms in children varied between nasal allergy in 19.6% of children, skin allergy (Eczema and urticarial)in 25.2% of children, childhood asthma in 31.5% of children. The rate of development of allergic symptoms in the presence of two factors (family history and high total immunoglobulin E in umbilical cord blood) was 51.7%. Conclusion: We found a high Prevalence of allergic diseases in children with high total immunoglobulin E in umbilical cord blood. The Current study could be used as a preventative strategy to reduce the risk of allergic diseases by predictive of subsequent
Background Subcutaneous Immunotherapy is an effective treatment for allergic diseases. It decreases the new sensitizations in individuals who were monosensitized. It may be associated with mild local symptoms with difficult to apply in children. The aim of the current study is to compared Sublingual Immunotherapy versus Subcutaneous Injection Immunotherapy in Children with House Dust Mite allergy. Methods In an open-label randomized clinical trial included 20 children aged (6–13) years with House Dust Mite allergic asthma and/ or rhinitis who were admitted to Al Assad University Hospital over 1 year between January 2014 to January 2015. The patients were divided into 2 groups according to a randomized schedule, one of them was treated with Subcutaneous Injection Immunotherapy (SCIT), and the other received Sublingual Immunotherapy (SLIT). We monitored the patients every 3 months over 1 year to evaluate the clinical improvement, side effects of the treatment, drug dependence. Results The current study showed remarkable and fast improvement of the clinical symptoms with a decrease in the need for the medication in the Sublingual Immunotherapy group compared to the Subcutaneous Injection Immunotherapy group with a significant difference. There was no difference observed in safety between the two groups, and side effects were mild in both groups. Conclusion The current study confirmed that the use of the Sublingual Immunotherapy group is more rapid and effective in children with allergic diseases.
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