Objetive: To identify the prevalence of gestational and congenital syphilis reported in the System of Information of Notifiable Diseases between the years 2011 to 2016, in the municipality of Francisco Beltrão -state of Paraná. Method: This is an epidemiological, documentary and retrospective study with a quantitative approach. Data were collected through a structured script, and statistically analyzed. Results: Thirty nine cases of gestational syphilis, and 8 cases of congenital syphilis were reported. Of the cases of gestational syphilis, the age range between 20 and 29 years prevailed (51.3%). The third trimester of gestation presented the highest number of notifications (29, 74.3%). Regarding clinical classification, the primary form prevailed with 15 cases (38.5%). Conclusion: It is concluded that the municipality requires a greater commitment of the health professionals to guarantee the quality of the notifications, and to ensure strategies of education, prevention, detection and early treatment for cases of gestational and congenital syphilis.

Deleterious effects have been widely associated with chronic pesticide exposure, including cancer development. In spite of several known consequences that pesticides can trigger in the human body, few is known regarding its impact on breast cancer women that are chronically exposed to such substances during agricultural work lifelong. In this context, the present study performed a high-throughput toxicoproteomic study in association with a bioinformatics-based design to explore new putative processes and pathways deregulated by chronic pesticide exposure in breast cancer patients. To reach this goal, we analyzed comparatively non-depleted plasma samples from exposed (n = 130) and non-occupationally exposed (n = 112) women diagnosed with breast cancer by using a label-free proteomic tool. The list of proteins differentially expressed was explored by bioinformatics and the main pathways and processes further investigated. The toxicoproteomic study revealed that women exposed to pesticides exhibited mainly downregulated events, linked to immune response, coagulation and estrogen-mediated events in relation to the unexposed ones. Further investigation shown that the identified deregulated processes and pathways correlated with significant distinct levels tumor necrosis factor alpha and interleukin 1 beta in the blood, and specific clinicopathological characteristics pointed out by bioinformatics analysis as adipose-trophic levels, menopause and intratumoral clots formation. Altogether, these findings reinforce pesticides as downregulators of several biological process and highlight that these compounds can be linked to poor prognosis in breast cancer.

Objective: To characterize the profile of occupational exposure to pesticides and its impact on women's health. Method: This is a prospective and descriptive study with a quantitative approach. The study population included all patients attended at Francisco Beltrao Cancer Hospital (Ceonc) from May 2015 to December 2018 (n=315). The characterization of their exposure profile was obtained through an interview using a form applied by trained researchers contained 60 questions related to women's pesticide exposure and their health status. The questions referred to past and current occupational pesticide exposure profile, intoxication, and health history from women and their families. All collected data were analyzed in the Statistical Package for the Social Sciences package (SPSS 25.0). Results: A total of 265 individuals (84.2%) have lived some part of their life in the countryside, and 70% were categorized as occupationally exposed to pesticides. Most of them (57%) were directly exposed, mainly by washing pesticide-contaminated clothes and personal protective equipment used in pesticide pulverization without glove protection. Cancer cases in the family were the main disease reported (68.3%). Further, 57% of interviewed women had a breast cancer diagnosis but no significance between breast cancer occurrence and pesticide exposure was observed. Conclusion: The form allowed us to characterize the profile of occupational pesticide exposition in rural women, alerting them to their severe contamination. This approach can be useful to characterize the occupational exposure profiles of rural workers living in other rural regions of Brazil that use pesticides.

Objetivo: conhecer as percepções de gestantes internadas em um serviço de referência em alto risco sobre gerar um filho com alguma doença preexistente e descrever a expressão de sentimentos ao vivenciarem a experiência de desenvolver uma gestação na situação de risco. Método: trata-se de estudo descritivo de abordagem qualitativa, realizado com 18 gestantes que se encontravam na maternidade do Hospital Regional do Sudoeste do Paraná, por meio de entrevista semiestruturada. A coleta foi realizada entre os meses de abril e junho de 2017. Resultados: delinearam-se duas categorias e foi possível constatar que essas gestantes sentem-se muitas vezes despreparadas para gerar um filho, mudam toda sua rotina de vida e entregam seu futuro nas mãos de Deus, vindo à tona o medo, preocupação, insegurança, ansiedade, felicidade e culpa. Conclusão: o estudo revelou a necessidade que essas gestantes apresentam de expressar seus sentimentos, porém, esse lado da maternidade é, muitas vezes, negligenciado, não sendo evidenciada pelos profissionais a influência significativa que oferece no desenvolvimento da gestação. Palavras-chave: Complicações na Gravidez; Gestantes; Gravidez de Alto Risco. ABSTR ACT Objective: to understand the perceptions of pregnant women admitted to a highrisk reference service about having a child with a pre-existing disease and to describe their feelings when going through the experience of developing a high-risk pregnancy. Method: this is a descriptive study of a qualitative approach, conducted through a semi-structured interview with 18 pregnant women who were in the maternity ward of the Hospital Regional do Sudoeste do Paraná. Data was collected between April and June 2017. Results: two categories were delineated and it was found that these pregnant women often feel unprepared to have a child, to change their whole life and to place their future in the hands of God, raising fear, concern, insecurity, anxiety, happiness and guilt. Conclusion: the study revealed the need that these pregnant women have to express their feelings; however, this aspect of motherhood is often neglected, and the significant influence on the development of pregnancy is not evidenced by the professionals.

Objective: to analyze the association between maternal difficulties in home care for newborns and parity. Methods: cross-sectional study, carried out in Primary Health Care in a Brazilian municipality. The sample consisted of 247 puerperal women, whose data collection took place by using two questionnaires, applied in home visits. The data were analyzed using Pearson’s chi-square test. Results: it was observed that both primiparous and multiparous women had a very high percentage of difficulties related to care, however, primigravid women showed greater obstacles in the care related to bathing and belching while multiparous women reported greater obstacles during breastfeeding. The worry with the choice of clothes and the umbilical stump was statistically significant, regardless of the number of gestations. Conclusion: there were difficulties, regardless of the woman’s previous obstetric experience, being mainly associated with insecurity, concern, and helplessness.