Current knowledge of the phenotype of mononuclear cells accumulating in pancreatic islets in insulin-dependent diabetes (IDDM) and factors determining their homing into the pancreas is limited. Therefore, a pancreas obtained at the onset of IDDM was studied in detail. Cryostat sections were stained for mononuclear cell types, T cell receptor subtypes, and adhesion molecules of vascular endothelium and studied by immunofluorescence microscopy, and peripheral blood mononuclear cells were phenotyped using flow cytometry. Monocytes/macrophages (lysozyme-or CD 14-reactive cells) were identified among other mononuclear cell types in islet infiltrates. Vft

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The connection between self-reported depressive symptoms at age 8 and ideation and acts of deliberate self-harm at age 18 is a good reason to already pay special attention to children's own intimations of distress in elementary school. It is likely that an effective way to prevent suicidality among adolescents is to search for and treat psychiatric problems among young people. Self-reported screening questionnaires used, e.g. in school healthcare, may provide an opportunity to recognize these problems.

Our findings provide the first evidence of an association between mental health problems during childhood and increased risk of specific physical health problems, mainly asthma and obesity, during early adulthood, in a representative sample of males over time. These data suggest that behavioral and emotional problems in childhood may signal vulnerability to chronic physical health problems during early adulthood.

Objective To examine whether mental health problems in childhood increase the likelihood of overweight or obesity during early adulthood among male subjects. Study design In a national prospective population-based study conducted in Finland, child mental health, including depression, emotional problems, conduct problems, and hyperactivity (determined on the basis of child, parent, and teacher information), was assessed at age 8 years. Body mass index (BMI) was obtained from military examination records (n = 2209) conducted in early adulthood (age range, 18–23 years). Results Both moderate (50th–90th percentile) and high (>90th percentile) levels of conduct problems at age 8 years were prospectively associated with a young adult being obese (BMI ≥ 30; odds ratio [OR], 2.0; 95% CI, 1.2–3.2; and OR, 2.9; 95% Confidence interval [CI], 1.5–5.9; respectively). Conduct problems were also prospectively associated with a young adult being overweight (25 ≤ BMI < 30; OR, 1.5; 95% CI, 1.1–1.9 for moderate levels of conduct problems, and OR, 1.9; 95% CI, 1.2–2.8 for high levels), after controlling for hyperactive problems and sociodemographic factors. Conclusions Conduct problems in childhood are prospectively associated with overweight and obese in young adulthood. Future studies should address the potential for interventions to reduce obesity risk in young adulthood for boys who manifest conduct problems early in life.