Infection spreading in cell culture occurs due to virus replication in infected cells and its random motion in the extracellular space. Multiplicity of infection experiments in cell cultures are conventionally used for the characterization of viral infection by the number of viral plaques and the rate of their growth. We describe this process with a delay reaction-diffusion system of equations for the concentrations of uninfected cells, infected cells, virus, and interferon. Time delay corresponds to the duration of viral replication inside infected cells. We show that infection propagates in cell culture as a reaction-diffusion wave, we determine the wave speed and prove its existence. Next, we carry out numerical simulations and identify three stages of infection progression: infection decay during time delay due to virus replication, explosive growth of viral load when infected cells begin to reproduce it, and finally, wave-like infection progression in cell culture characterized by a constant or slowly growing total viral load. The modelling results are in agreement with the experimental data for the coronavirus infection in a culture of epithelial cells and for some other experiments. The presence of interferon produced by infected cells decreases the viral load but does not change the speed of infection progression in cell culture. In the 2D modelling, the total viral load grows faster than in the 1D case due to the increase of plaque perimeter.
Abstract. In this note we are interested in the modelling of sediment transport phenomena. We mostly focus on bedload transport and we do not consider suspension sediment processes. We first propose a numerical scheme for the classical Saint-Venant -Exner model. It is based on a relaxation approach for the whole system and it works with all sediment flux function. The stability of the scheme is investigated and some numerical tests are proposed. We exhibit that this coupled approach is more stable than the splitting approach that is mostly used in industrial softwares. Then we derive an original three layers model in order to overcome the difficulties that are encountered when using the classical Exner approach and we present a related relaxation model.
In this paper we consider the numerical solution of Boussinesq-Peregrine type systems by the application of the Galerkin finite element method. The structure of the Boussinesq systems is explained and certain alternative nonlinear and dispersive terms are compared. A detailed study of the convergence properties of the standard Galerkin method, using various finite element spaces on unstructured triangular grids, is presented. Along with the study of the Peregrine system, a new Boussinesq system of BBM-BBM type is derived. The new system has the same structure in its momentum equation but differs slightly in the mass conservation equation compared to the Peregrine system. Further, the finite element method applied to the new system has better convergence properties, when used for its numerical approximation. Due to the lack of analytical formulas for solitary wave solutions for the systems under consideration, a Galerkin finite element method combined with the Petviashvili iteration is proposed for the numerical generation of accurate approximations of line solitary waves. Various numerical experiments related to the propagation of solitary and periodic waves over variable bottom topography and their interaction with the boundaries of the domains are presented. We conclude that both systems have similar accuracy when approximate long waves of small amplitude while the Galerkin finite element method is more efficient when applied to BBM-BBM type systems.
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